Publications by authors named "Edwige Daronnat"
Skin metabolism is becoming a major consideration in the development of new cosmetic ingredients, skin being the first organ exposed to them. In order to replace limited samples of Excised human skin (EHS), in vitro engineered human skins have been developed. 3D models are daily used to develop and evaluate new cosmetic ingredients and have to be characterized and compared with EHS in terms of metabolic capabilities.
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- TRP-2, an enzyme involved in melanin production, impacts how melanocytes respond to stress and was studied in the WM35 melanoma cell line.
- Overexpressing TRP-2 increased cell survival against oxidative stress, protected DNA from damage, and raised glutathione levels, a key antioxidant.
- However, the protective effects of TRP-2 were not observed in HEK epithelial cells, suggesting the benefits depend on the specific cell type or environment.