Examining Discrimination as a Distal Moderator of the Proximal Association Between LGBQ+ College Students' Alcohol Use and Cyber Dating Abuse.

Comprehensive and inclusive dating abuse prevention is hindered by a lack of research on proximal antecedents of cyber dating abuse (CDA) among lesbian, gay, bi-/pansexual, queer, and other nonheterosexual (LGBQ+) young adults. Guided by sexual minority stress and alcohol-related violence theories, we addressed this gap by examining whether (a) alcohol use preceded and was positively related to CDA perpetration and (b) more frequent LGBQ+-based discrimination strengthened this association. LGBQ+ college students ( = 41; 75.

Transfer of musculoskeletal care from paediatric to adult services for patients with cerebral palsy and chronic neuromuscular conditions: Identifying the unmet need.

Introduction: Children with cerebral palsy (CP) are treated by well-co-ordinated multi-disciplinary neuromuscular teams. With a comprehensive multidisciplinary team, co-ordinating the transfer to adult care is a challenge. Orthopaedic care becomes fragmented as patients transfer from paediatric orthopaedic surgeons with training in multi-joint neuromuscular conditions (NMCs), to adult orthopaedic surgeons where this expertise rarely exists.

USP34 regulates endothelial PAR1 mRNA transcript expression and cellular signaling.

Signaling by G protein-coupled receptors (GPCRs) is regulated by temporally distinct processes including receptor desensitization, internalization, and lysosomal sorting, and are tightly controlled by post-translational modifications. While the role of phosphorylation in regulating GPCR signaling is well studied and established, the mechanisms by which other post-translational modifications, such as ubiquitination, regulate GPCR signaling are not clearly defined. We hypothesize that GPCR ubiquitination and deubiquitination is critical for proper signaling and cellular responses.

Improving the arthritis component of the SLEDAI-2K.

Objective: To propose a new definition for SLEDAI arthritis informed by imaging.

Methods: We performed a planned secondary analysis of observational data from a multicentre study evaluating SLE patients with inflammatory joint pain (swelling not required) using various clinical instruments, laboratory tests and ultrasound. For SLEDAI arthritis, assessors (blinded to ultrasound) were asked which of the glossary terms for arthritis in any version of the SLEDAI drove their decision to score for arthritis.

Is COVID-19 Still a Threat? An Expert Opinion Review on the Continued Healthcare Burden in Immunocompromised Individuals.

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound global impact. The emergence of several variants during the pandemic has presented numerous challenges in preventing and managing this disease. The development of vaccines has played a pivotal role in controlling the pandemic, with a significant portion of the global population being vaccinated.

Consensus Guideline for Care of Patients in the Prehospital and Aerospace Settings with Exposures to Hydrazine and Hydrazine Derivatives.

Objectives: Hydrazine (HZ) and Hydrazine Derivative (HZ-D) exposures pose health risks to people in industrial and aerospace settings. Several recent systematic reviews and case series have highlighted common clinical presentations and management strategies. Given the low frequency at which HZ and HZ-D exposures occur, a strong evidence base on which to develop an evidence-based guideline does not exist at this time.

Can a Surgical Vulnerability Score Predict Outcomes of Hip Reconstruction in Children with Severe Neuromuscular Disability?

Background: Hip surgery is often necessary for children with severe neuromuscular disabilities to avoid chronic pain resulting from hip migration. This study correlated the Surgical Vulnerability Score (SVS), a novel measure of physiological reserve, with reconstructive hip surgery outcomes to improve shared surgical decision-making.

Materials And Methods: Sixty-eight cases performed by a single surgeon were retrospectively evaluated.

The worst of times: Using a transformative mixed-methods study to name and describe school-based adverse racialized experiences (AREs) in the K-12 retrospective accounts of university students.

Objective: This transformative multiphase mixed-methods study aimed to identify the thematic structure of school-based adverse racialized experiences (AREs), their prevalence, and perpetrators in the retrospective K-12 accounts of a sample of racially diverse undergraduate students aged 17-22.

Method: Interpretative analysis of interviews in Phase I informed the design of a vignette survey in Phase II. Qualitative and quantitative methods identified convergent patterns of school-based AREs under the three themes: racial discrimination, racial microaggressions, and racial harassment.

Impact of Cleft and Craniofacial Surgery Experience in Oral and Maxillofacial Surgery Residency Training Programs.

Background: The impact of cleft and craniomaxillofacial (CCMF) surgeons on oral and maxillofacial surgery (OMS) resident training is not well known.

Purpose: The purpose of this study was to measure the association between resident exposure to OMS faculty with CCMF surgery training, clinical experience, and scholarly activity.

Study Design, Setting, Sample: An anonymous survey of OMS residency directors in the United States, distributed electronically by the American Association of Oral and Maxillofacial Surgeons, was used to conduct a cross-sectional study.

"There's no us vs. them, it's just us": a creative approach to centring lived experience within the AVATAR2 trial.

This article describes a Patient and Public Involvement (PPI) led creative workshop space held within a clinical trial of a talking therapy for distressing voices (AVATAR2). PPI adds significant value to clinical research and ensures the work is meaningful to patients and their supporters. However, known issues include tokenism, a common power imbalance between PPI colleagues and researchers and a lack of opportunity for PPI to shape the research.

Survey-based inference of continental African elephant decline.

Long-term quantification of temporal species trends is fundamental to the assignment of conservation status, which in turn is critical for planning and targeting management interventions. However, monitoring effort and methodologies can change over the assessment period, resulting in heterogeneous data that are difficult to interpret. Here, we develop a hierarchical, random effects Bayesian model to estimate site-level trends in density of African elephants from geographically disparate survey data.

Developing guidelines on EFT for same-sex/gender relationships: Recommendations from a Delphi study.

Emotionally focused therapy (EFT) is one of few empirically supported treatments for relationship distress. While evidence-based approaches are critical for ensuring safe and effective treatment, EFT has not been adapted for use with same-sex/same-gender (SS/SG) relationships. This study used the Delphi method to generate consensus on treatment guidelines for using EFT with SS/SG relationships.

Engineered Immune Constructs Alter Antigen-Specific Immune Tolerance and Confer Durable Protection in Myelin-Driven Autoimmunity.

Autoimmune diseases are broadly characterized as a failure in immune tolerance. In multiple sclerosis (MS), autoreactive immune cells attack the protective myelin sheath lining neurons in the central nervous system. Therapeutic strategies that selectively and durably restore immune tolerance without broad immunosuppression are urgently needed for MS.

Olfactory combinatorial coding supports risk-reward decision making in .

Olfactory-driven behaviors are essential for animal survival, but mechanisms for decoding olfactory inputs remain poorly understood. We have used whole-network Ca imaging to study olfactory coding in We show that the odorant 1-octanol is encoded combinatorially in the periphery as both an attractant and a repellant. These inputs are integrated centrally, and their relative strengths determine the sensitivity and valence of the behavioral response through modulation of locomotory reversals and speed.

Fossil amphibian offers insights into the interplay between monsoons and amphibian evolution in palaeoequatorial Late Triassic systems.

The severe greenhouse climate and seasonality of the early to mid-Late Triassic are thought to have limited terrestrial diversity at lower latitudes, but direct adaptations to these harsh conditions remain limited in vertebrates at the palaeoequator. Here, we present gen. et sp.