The Makorin and the lncRNA regulate to schedule sexual maturation of the nervous system.

Sexual maturation must occur on a controlled developmental schedule. In mammals, Makorin3 () and the miRNA regulators are key regulators of this process, but how they act is unclear. In , sexual maturation of the nervous system includes the functional remodeling of postmitotic neurons and the onset of adult-specific behaviors.

The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.

Biological roles for most long non-coding RNAs (lncRNAs) remain mysterious. Here, using forward genetics, we identify lep-5, a lncRNA acting in the C. elegans heterochronic (developmental timing) pathway.