Publications by authors named "Edward Tri Nguyen"
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women in the United States. In clinical practice, the standard method to confirm metastatic disease and tailor treatment is to biopsy a metastatic site. Bone is the most common metastatic site, occurring in up to 70% of patients with advanced breast cancer.
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- - Breast cancer is a leading cause of cancer deaths in women in the U.S., and this study explores the use of liquid biopsies to analyze circulating-tumor DNA (ctDNA) in metastatic breast cancer (mBC) patients to improve understanding of their genomic profiles.
- - Researchers studied ctDNA from 45 mBC patients using the Guardant360 test, finding that 86.7% of them had at least one genetic alteration; age and cancer subtype were linked to differences in mutations, while race showed no significant impact.
- - Key mutations identified included TP53, PIK3CA, and ESR1, with the study highlighting that liquid biopsies provide crucial information for treatment decisions in hormone-positive mBC, suggesting their