Publications by authors named "Edward P Cheng"
Imaging Utilization and Outcomes in Vulnerable Populations during COVID-19 in New York City.
Radiol Cardiothorac Imaging
December 2020
Background: Coronavirus disease 2019 (COVID-19) affects vulnerable populations (VP) adversely.
Purpose: To evaluate overall imaging utilization in vulnerable subgroups (elderly, racial/ethnic minorities, socioeconomic status [SES] disadvantage) and determine if a particular subgroup has worse outcomes from COVID-19.
Materials/methods: Of 4110 patients who underwent COVID-19 testing from March 3-April 4, 2020 at NewYork-Presbyterian Hospital (NYP) health system, we included 1121 COVID-19 positive adults (mean age 59±18 years, 59% male) from two academic hospitals and evaluated imaging utilization rates and outcomes, including mortality.
Inpatient hospital procedural volume and outcomes following catheter ablation of atrial fibrillation.
J Cardiovasc Electrophysiol
August 2020
Article Synopsis
- The study investigates how the volume of atrial fibrillation (AF) ablation procedures at hospitals affects patient outcomes, focusing on complications and readmission rates between 2010 and 2014.
- It found that the majority of hospitals performing AF ablations (79.3%) were low volume centers, which showed higher complication and early mortality rates compared to higher volume hospitals.
- Patients at low volume hospitals tended to be older and had more associated health issues, leading to significantly poorer outcomes such as increased risks of cardiac perforation and mortality.
Background: By virtue of its proximity to structures vital to cardiac conduction, aortomitral continuity calcification (AMCC) may help identify patients at highest risk for developing atrioventricular conduction disease requiring permanent pacemaker implantation (PPMI). We aim to determine the association of AMCC and need for PPMI after transcatheter aortic valve replacement.
Methods: Of 614 patients who underwent transcatheter aortic valve replacement (11.
Risk of Mortality Following Catheter Ablation of Atrial Fibrillation.
J Am Coll Cardiol
November 2019
Article Synopsis
- The study investigates early mortality rates after catheter ablation for atrial fibrillation (AF), using a large database of patient admissions from 2010 to 2015.
- Early mortality was found to be 0.46%, with over half of the deaths happening during readmission within 30 days after the procedure.
- Key factors linked to early mortality include procedural complications, congestive heart failure, and low hospital experience with AF ablation procedures.
Article Synopsis
- Catheter ablation for atrial fibrillation (AF) shows significant sex-based differences, with women experiencing higher rates of complications and readmissions compared to men.
- A study of over 54,000 patients revealed that 37.7% were female, and women had increased risks for complications, including cardiac perforation and bleeding.
- Despite these complications, the overall costs of AF ablation were lower for women due to less resource usage, highlighting the need for further exploration of sex disparities in AF management.
Ca(2+) flux through l-type CaV1.2 channels shapes the waveform of the ventricular action potential (AP) and is essential for excitation-contraction (EC) coupling. Timothy syndrome (TS) is a disease caused by a gain-of-function mutation in the CaV1.
View Article and Find Full Text PDFVoltage-gated, dihydropyridine-sensitive L-type Ca(2+) channels are multimeric proteins composed of a pore-forming transmembrane α(1) subunit (Ca(v)1.2) and accessory β, α(2)δ, and γ subunits. Ca(2+) entry via Ca(v)1.
View Article and Find Full Text PDFCa2+ signaling amplification by oligomerization of L-type Cav1.2 channels.
Proc Natl Acad Sci U S A
January 2012
Ca(2+) influx via L-type Ca(v)1.2 channels is essential for multiple physiological processes, including gene expression, excitability, and contraction. Amplification of the Ca(2+) signals produced by the opening of these channels is a hallmark of many intracellular signaling cascades, including excitation-contraction coupling in heart.
View Article and Find Full Text PDFRationale: L-type Ca(2+) (Ca(V)1.2) channels shape the cardiac action potential waveform and are essential for excitation-contraction coupling in heart. A gain-of-function G406R mutation in a cytoplasmic loop of Ca(V)1.
View Article and Find Full Text PDFRationale: L-Type (Cav1.2) Ca(2+) channels are critical regulators of muscle and neural function. Although Cav1.
View Article and Find Full Text PDF