Publications by authors named "Edward Moto"

Article Synopsis
  • Pediatric meningitis poses a significant global health challenge, particularly in low-resource settings where the pathogens involved and their antibiotic resistance are poorly understood, prompting a study in Kampala, Uganda.
  • The study used metagenome binning and antibiotic susceptibility testing to identify pathogens associated with infant meningitis, revealing two strains (ST242 and ST∗1b23) that showed considerable resistance to commonly used antibiotics, including ceftriaxone.
  • Analysis of the virulence factors of these strains indicated mechanisms that target and disrupt the blood-brain barrier, suggesting that coinfection and interactions between these pathogens may complicate the treatment of meningitis and undermine the efficacy of ceftriaxone.
View Article and Find Full Text PDF

The Klebsiella oxytoca complex comprises diverse opportunistic bacterial pathogens associated with hospital and community-acquired infections with growing alarming antimicrobial resistance. We aimed to uncover the genomic features underlying the virulence and antimicrobial resistance of isolates from Mulago National Hospital in Uganda. We coupled whole genome sequencing with Pathogenwatch multilocus sequence typing (MLST) and downstream bioinformatic analysis to delineate sequence types (STs) capsular polysaccharide K- and O-antigen loci, along with antimicrobial resistance (AMR) profiles of eight clinical isolates from the National Referral Hospital of Uganda.

View Article and Find Full Text PDF

has emerged as a species with potential for versatile nonribosomal peptides and polyketides of therapeutic importance, including antibiotics. From our molecular bioprospecting project, we report a full genome of strain MARUCo01 locally isolated from sediments of the Indian Ocean along the coast of Bagamoyo in Tanzania.

View Article and Find Full Text PDF

is a genus of biotechnologically important bacteria adapted to thrive in a wide range of environmental conditions including the marine sediments. Here, we screened and isolated a strain from the Bagamoyo marine mangrove-inhabited sediments and then employed whole genome sequencing to recover and define its full genome. -assembly with Unicycler (v.

View Article and Find Full Text PDF