Publications by authors named "Edward Michael Gertz"
Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis.
Cancers (Basel)
July 2021
Purpose: Older breast cancer patients are underrepresented in cancer research even though the majority (81.4%) of women dying of breast cancer are 55 years and older. Here we study a common phenomenon observed in breast cancer which is a large inter- and intratumor heterogeneity; this poses a tremendous clinical challenge, for example with respect to treatment stratification.
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- Researchers studied different types of colorectal cancer cells to see how their chromosomes change and why this matters for treatment.
- They found that some cell lines had stable chromosomes, while others were unstable and mixed up.
- By looking closely at how these cells grow and change over time, they discovered that certain cells keep changing, while others stay more consistent, which helps them understand how cancer develops.
Background: PSEUDOMARKER is a software package that performs joint linkage and linkage disequilibrium analysis between a marker and a putative disease locus. A key feature of PSEUDOMARKER is that it can combine case-controls and pedigrees of varying structure into a single unified analysis. Thus it maximizes the full likelihood of the data over marker allele frequencies or conditional allele frequencies on disease and recombination fraction.
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