Publications by authors named "Edward Meigs Brown"
Strontium ranelate decreases receptor activator of nuclear factor-ΚB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor.
Axelle Caudrillier Anne-Sophie Hurtel-Lemaire Alice Wattel Fabienne Cournarie Corinne Godin Edward Meigs Brown
Mol Pharmacol
October 2010
Article Synopsis
- - Strontium ranelate has both anticatabolic (prevents bone breakdown) and anabolic (promotes bone formation) effects on bone cells, reducing bone resorption significantly when using higher concentrations of Sr(o)(2+).
- - The study found that increased Sr(o)(2+) concentrations lead to decreased osteoclastic differentiation and activity, particularly by inhibiting the function of RANKL, a key factor in bone cell formation.
- - Findings suggest that the calcium-sensing receptor (CaR) plays a crucial role in this inhibition process, suggesting that strontium may help manage bone health by impacting how osteoclasts (bone-resorbing cells) form and function.