Publications by authors named "Edward M Huddleston"
Article Synopsis
- Methotrexate is a commonly prescribed medication for various rheumatic diseases like rheumatoid arthritis and systemic lupus erythematosus, originally developed for cancer treatment in the 1960s and approved for RA in 1988.
- It has been used for medical abortions and can cause serious birth defects, affecting 6%-10% of pregnant women taking it, making its use complex in light of current abortion policies in the U.S. after the Dobbs ruling.
- The Dobbs decision has influenced healthcare providers' and patients' views on methotrexate, suggesting an expanded role for rheumatologists in addressing patients' reproductive health concerns.
Gout is a common and potentially debilitating disease characterized by a painful inflammatory arthritis ("gout flare"), caused by the deposition of monosodium urate crystals in joints and surrounding tissues. Gout is frequently comorbid with other chronic conditions such as chronic kidney disease (CKD) and diabetes mellitus, which can make treatment complex, as traditional mainstays (such as allopurinol, colchicine, and corticosteroids) may not be preferred or could have adverse events in such patients. Understanding the pathophysiology of hyperuricemia, gout, and crystalline-driven inflammation is key for drug development and research.
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