Antimalarials and Phytotoxins from Identified from a Seed of Diseased .

The metabolic pathways in the apicoplast organelle of parasites are similar to those in plastids in plant cells and are suitable targets for malaria drug discovery. Some phytotoxins released by plant pathogenic fungi have been known to target metabolic pathways of the plastid; thus, they may also serve as potential antimalarial drug leads. An EtOAc extract of the broth of the endophyte isolated from a seed collected from a plant with disease symptoms, showed in vitro antimalarial and phytotoxic activities.

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, sp. UM10M, Isolated from a Diseased Leaf.

Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus sp. UM10M (Xylariaceae) isolated from a diseased leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C () and D (), and 18-deoxy-19,20-epoxy-cytochalasin C (). All three compounds showed potent in vitro antiplasmodial activity and phytotoxicity with no cytotoxicity to Vero cells.

Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC-MS and RP-HPLC.

This study presents a new and validated HPLC method for the simultaneous determination of bioactive compounds in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea. The iridoid loganic acid, four secoiridoids and 29 xanthones were separated on a RP-18 column, using aqueous o-phosphoric acid (0.085%, v/v) and acetonitrile as mobile phase.