Alteration of the pattern of regenerative corneal subbasal nerves after laser in-situ keratomileusis surgery.

Purpose: Corneal nerves exhibit high plasticity, which allows successful reinnervation after nerve damage caused by laser in-situ keratomileusis (LASIK) surgery. This study aimed to examine corneal subbasal nerve orientation during regeneration after LASIK.

Methods: This study involved 20 healthy, myopic subjects who had undergone bilateral Femto-LASIK 12-16 months prior with a superior hinge position.

Corneal Sensitivity After Ocular Surgery.

The cornea is densely innervated with free nerve endings to provide a high level of sensitivity to foreign bodies or noxious substances. They also provide trophic support to the tissues of the cornea and facilitate their repair and replacement. Any reduction in the function of the nerve endings through disease, contact lens wear, or surgery may lead to corneal disease, damage, or reduced healing.

Effects of ambient humidity on the Cochet-Bonnet aesthesiometer.

Purpose: The Cochet-Bonnet (COBO) aesthesiometer is the current standard in corneal sensitivity assessment. This study investigates the influence of ambient room humidity levels on the stimulus force exerted by the instrument.

Methods: A COBO instrument (Luneau Opthalmologie) with 0.

Corneal Nerve Morphology and Tear Film Substance P in Diabetes.

Purpose: This work aims to characterize the relationship between tear film neuropeptide substance P and the structural integrity of the sub-basal nerve plexus in diabetes.

Methods: Seventeen healthy control participants and nine participants with diabetes were recruited in this cross-sectional study. Total protein content and substance P concentrations were determined in the flush tears of participants.

Changes in corneal subbasal nerve morphology and sensitivity during orthokeratology: Recovery of change.

Purpose: To investigate the recovery of orthokeratology (OK)-induced changes in corneal nerve morphology and sensitivity following lens wear discontinuation, over a 3-month period.

Methods: Sixteen myopic subjects who wore OK lenses during sleep for 3 months discontinued lens wear for 3 months. Corneal nerve morphology and sensitivity were assessed on the right eye only 3 h after waking at the pre-lens wear baseline and after lens wear discontinuation.

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change.

Purpose: To investigate changes in corneal subbasal nerve fiber density and orientation during a 3-month orthokeratology (OK) lens wear period and their relationship with concurrent changes in corneal sensitivity.

Methods: Sixteen subjects wore overnight OK lenses for 90 days and were assessed at baseline, Day 30, and Day 90. Nerve images at the corneal apex and temporal mid-periphery were captured from the right eye only using in vivo confocal microscopy and analyzed to calculate nerve fiber density (NFD) and global nerve fiber orientation (GNFO).

Reduced Corneal Sensitivity and Sub-Basal Nerve Density in Long-Term Orthokeratology Lens Wear.

Objectives: To investigate changes in corneal sensitivity and nerve morphology in orthokeratology (OK) contact lens wear.

Methods: In a cross-sectional study, 54 subjects (aged 18-45 years) were grouped into three categories: nonlens (NL), soft lens (SCL), and OK lens wearers. Corneal sensitivity was measured at the corneal apex and 2.

Treatment Zone Decentration During Orthokeratology on Eyes with Corneal Toricity.

Purpose: To compare the magnitude of treatment zone decentration between eyes with minimally toric corneas (≤1.50 DC, LoTor group) and eyes with moderately toric corneas (1.50 to 3.

Myopia control during orthokeratology lens wear in children using a novel study design.

Purpose: To investigate the effect of overnight orthokeratology (OK) contact lens wear on axial length growth in East Asian children with progressive myopia.

Design: A prospective, randomized, contralateral-eye crossover study conducted over a 1-year period.

Participants: We enrolled 26 myopic children (age range, 10.

Central and paracentral corneal curvature changes during orthokeratology.

Purpose: To investigate regional changes in corneal curvature and power induced by overnight orthokeratology (OK) contact lens wear over a period of 2 weeks.

Methods: Corneal topography data (Medmont E300) from 21 myopes (12 M, 9F, 20 to 40 years), who had worn BE OK lenses manufactured in Boston XO material for 14 nights, were analyzed retrospectively. Enrollment criteria were myopia up to 4.

Corneal sensitivity with contact lenses of different mechanical properties.

Purpose: To examine the changes in corneal sensitivity after overnight wear of contact lenses with different mechanical properties.

Methods: Twenty young-adult subjects wore a silicone hydrogel, rigid gas-permeable, or orthokeratology (OK) contact lens in randomized order for a single night of wear in the right eye only. All lenses were matched in Dk/t (∼46 ISO Fatt).

Mapping the corneal sub-basal nerve plexus in orthokeratology lens wear using in vivo laser scanning confocal microscopy.

Purpose: This study was designed to map the sub-basal nerve plexus (SBNP) in the cornea of orthokeratology (OK) lens wearers.

Methods: Laser scanning confocal microscopy (LSCM) was performed in vivo on three subjects: a non-lens wearer and two OK lens wearers. Scans were performed on the right eye while the left eye fixated a moving target.

Lens Dk/t influences the clinical response in overnight orthokeratology.

Purpose: To investigate the influence of lens oxygen transmissibility (Dk/t) on the clinical response to overnight (ON) orthokeratology (OK) lens wear over 2 weeks.

Methods: Eleven subjects (age, 20 to 39 years) were fitted with OK lenses (BE; Capricornia Contact Lens) in both eyes. Lenses in matched design/fitting but different materials (Boston EO and XO; nominal Dk/t: 26 and 46 ISO Fatt, respectively) were worn ON only in the two eyes over a 2-week period.

Fibrillary lines in overnight orthokeratology.

This case report describes the appearance of fibrillary lines in the anterior stroma of a 39-year-old Asian woman wearing overnight orthokeratology (OK) lenses. The fibrillary lines were fine, slightly curved and sub-epithelial, arranged in a band-like annulus in the corneal mid-periphery. The lines were not associated with epithelial staining, although a marked Fischer-Schweitzer corneal mosaic was noted after blinking.

Performance standards for toric soft contact lenses.

Purpose: To simplify the clinical assessment of toric soft contact lens (TSCL) on-eye behavior by establishing a set of standard clinical evaluation techniques. The likely performance range expected among the TSCL wearing population was determined for a series of lens designs and acceptable performance standards indicated for each variable.

Methods: Four prism-ballast, two peri-ballast and one dynamic stabilization TSCL designs were each worn by groups of 20 subjects in a nondispensing study.

Osmolality and buffering agents in soft contact lens packaging solutions.

Aim: The study determined the effects of packaging solution osmolality and buffering agent on soft contact lens parameters.

Methods: One lens type from each FDA contact lens material category was equilibrated to phosphate buffered saline (PBS) or borate buffered saline (BBS), at three osmolality concentrations: 270, 310 and 414 mOsmol/kg. Lens diameter (LD), base curve (BOZR) and back vertex power (BVP) were measured and compared to nominal packaging label values.