Publications by authors named "Edward Lew"
Article Synopsis
- Recent genomic studies classify esophageal adenocarcinoma (EAC) into two groups: true (tEAC) and probable (pEAC), based on tumor location relative to the gastroesophageal junction (GEJ).
- In a comparison of 146 male patients, tEAC showed distinct characteristics, such as smaller tumor size and better prognosis, particularly in early-stage cases, compared to pEAC.
- The study concluded that resection (surgical or endoscopic) leads to significantly better outcomes for EAC patients, highlighting the importance of distinguishing between these two groups for treatment plans.
Article Synopsis
- * The study analyzed 347 male patients, predominantly white, with median ages of 70, highlighting that EA had the longest median overall survival (62.9 months) compared to GEJA (33.4 months) and GA (38.1 months).
- * Prognostic factors that impacted survival include tumor location, size, differentiation, subtype, and TNM stage, with the research further categor
Article Synopsis
- Systemic lupus erythematosus (SLE) significantly affects African American women, who experience more severe symptoms and higher mortality rates compared to women of other races, with health disparities linked to socioeconomic factors.
- The role of racism, described as an unmeasured factor affecting health outcomes, has become more recognized in relation to SLE, highlighting the need for addressing structural injustices in healthcare.
- A framework for individual and national actions is proposed to tackle these disparities, advocating for healthcare as a fundamental human right and suggesting collaborative efforts to mitigate the impact of racism in healthcare access and treatment.
Before age 35, Holman hit over 0.500 at the University of California Los Angeles (UCLA); was recruited by professional baseball; led the Association of Interns and Medical Students and the International Union of Students in Denmark; had his passport confiscated; was stripped of a prestigious internship; shadowed by the Federal Bureau of Investigation ; grilled before a Senate committee on subversive activities; made a major medical discovery; and was recruited to be the new Chief of Medicine at Stanford. Holman was involved in building a leading academic institution.
View Article and Find Full Text PDFObjectives: We followed The Cancer Genome Atlas (TCGA) grouping criteria and conducted a clinicopathological cohort study in a unique patient population to gain insight into the pathobiology of esophageal adenocarcinoma (EAC) and adenocarcinoma of the gastroesophageal junction (AGEJ).
Methods: We studied and statistically compared the clinicopathological and prognostic features of both cancers in 303 consecutive patients treated at the Veterans Affairs Boston Healthcare System over a 20-year period using uniform criteria and standardized routines.
Results: Over 99% of patients were white men with a mean age of 69.
Creating a contemporary clerkship curriculum: the flipped classroom model in emergency medicine.
Int J Emerg Med
December 2016
Background: The teaching modality of "flipping the classroom" has garnered recent attention in medical education. In this model, the lecture and homework components are reversed. The flipped classroom lends itself to more interaction in "class" and theoretically improved clinical decision-making.
View Article and Find Full Text PDFRamucirumab is an antiangiogenesis agent targeting the vascular endothelial growth factor receptor-2 (VEGFR-2), approved to treat advanced gastric and colon cancer. In clinical trials, it was shown to cause a small increase in arterial thromboembolism compared to placebo, including cerebral and myocardial ischemia, which was not statistically significant. Detailed case reports are lacking and we here present one of the first case reports of stroke secondary to ramucirumab-induced in situ thrombosis.
View Article and Find Full Text PDFAsynchronous learning: student utilization out of sync with their preference.
Med Educ Online
July 2017
Background: Asynchronous learning is gaining popularity. Data are limited regarding this learning method in medical students rotating in emergency medicine (EM). In EM, faculty time is limited to give in-person lectures.
View Article and Find Full Text PDFContext: In rural areas of the United States, emergency departments (EDs) are often staffed by primary care physicians, as contrasted to urban and suburban hospitals where ED coverage is usually provided by physicians who are residency-trained in emergency medicine.
Purpose: This study examines the reasons and incentives for rural Oregon primary care physicians to cover the ED and their reported measures of confidence and priorities for additional training.
Methods: We conducted a cross-sectional survey of primary care physicians in rural Oregon who are members of the Oregon Rural Practice-Based Research Network (ORPRN).
Objectives: To examine DNA content abnormalities in patients with Barrett's esophagus (BE) who progress to esophageal adenocarcinoma, using image cytometric DNA analysis (ICDA) of formalin-fixed tissues.
Methods: Studies were performed on archived biopsies of BE patients' undergoing endoscopic surveillance before developing adenocarcinoma. A comparison group consisted of BE patients' free of cancer during a follow-up period of over 9 yr.