Publications by authors named "Edward J Bass"
Article Synopsis
- Diagnostic prostate biopsy methods have evolved significantly, shifting from finger-guided techniques to advanced MRI-directed strategies and transperineal approaches.
- The adoption of transperineal biopsy has decreased the risk of infections and enhanced antibiotic usage.
- Future advancements may include image fusion for 3D-ultrasonography, molecular targeting with PET imaging, and the use of robotic assistance in biopsies.
Article Synopsis
- Advances in systemic agents for metastatic prostate cancer have improved overall survival, leading to a need for better understanding patients' values and preferences for treatment.
- A systematic review was conducted across 15 studies with 1491 participants to assess patients' preferences regarding treatment options, highlighting treatment effectiveness and symptom delay as top priorities.
- The findings suggest that patients are willing to accept some treatment-related side effects in exchange for potential benefits, while concerns about cancer progression, pain, and fatigue emerged as important themes from qualitative studies.
Article Synopsis
- * The evidence supports using PSMA PET/CT not only for initial staging but also as a guide for targeted treatments in areas likely to have metastasis.
- * This imaging technique may serve as a valuable biomarker for monitoring disease progression and predicting responses to various cancer treatments in the future.
Article Synopsis
- - The study aimed to determine if patients with Gleason 3 + 4 prostate cancer (initially identified via regular biopsy) are reclassified after undergoing a more precise MRI-targeted biopsy, and what this means for clinical practices.
- - An analysis of 107 patients found that while 78.5% retained the same Gleason score, 21.5% were upgraded to higher-risk categories, indicating a significant upgrade in risk assessment (P = 0.0006).
- - The findings suggest that the targeted biopsy can change the risk classification of a significant portion of patients, which could affect decisions about treatment options, highlighting the need to update risk calculators with this new data as targeted biopsies become common. *
Article Synopsis
- This study aimed to assess a new diagnostic method for prostate cancer (PCa) using multiparametric MRI (mpMRI) and cognitive fusion transperineal targeted biopsy (MRTB), focusing on improving cancer detection and speeding up diagnosis and treatment times.
- Conducted at a tertiary referral center in the UK, 112 men referred under the UK 2-week wait guidelines participated, undergoing mpMRI followed by MRTB if necessary, with results ready within 48 hours.
- The results showed that 79% of those biopsied had cancer, with significant cases detected, and reduced the time to diagnosis and treatment to a median of 8 and 20 days respectively, suggesting this approach
Article Synopsis
- The study reviews major guidelines on evaluating and managing asymptomatic microscopic hematuria (AMH) from multiple health organizations.
- All guidelines recommended evaluation for AMH when benign causes are ruled out, involving procedures like cystoscopy and upper urinary tract imaging.
- There are notable differences in how these guidelines define AMH, specify age thresholds for evaluation, and recommend imaging methods, highlighting ongoing research opportunities in this area.
Focal therapy in prostate cancer: A review of seven common controversies.
Cancer Treat Rev
December 2016
Article Synopsis
- Radical treatments like prostatectomy and radiotherapy are effective for localized prostate cancer, improving survival rates.
- Cancer treatments should not only aim to cure but also minimize side effects for patients.
- Focal therapy targets specific areas of the prostate with significant disease, but it faces common criticisms, referred to as the "seven sins," that need to be further examined.
Article Synopsis
- - The study examines the effectiveness of locking vs. non-locking plates in the fusion of the first metatarsophalangeal joint (1st MTPJ), a common surgical procedure for forefoot issues.
- - Out of 172 MTPJ fusions analyzed, non-union rates were found to be 6.9%, with males showing a significantly higher failure rate (17.5%) compared to females (3.8%).
- - Results suggest that 1st MTPJ fusion is generally effective, and locking plates may enhance fusion rates, particularly for male patients.
Article Synopsis
- Rheumatoid arthritis commonly causes foot deformities like hallux valgus and clawed lesser toes, which can be treated surgically for relief and correction.
- A study involving 12 patients aged 55-71 assessed the effectiveness of a new surgical technique combining 1st metatarsophalangeal joint fusions with Stainsby procedures.
- Results showed significant improvement in patient outcomes, with mean AOFAS scores rising from 46 to 72 and notable reductions in hallux valgus angles after surgery.