Publications by authors named "Edvinas Chaleckas"

Intracranial pressure (ICP) monitoring is crucial in the management of traumatic brain injury (TBI) and other neurological conditions. Elevated ICP or too low intracranial compliance (ICC) can compromise brain perfusion. Simultaneous monitoring of ICP and ICC is needed to optimize patient-specific brain perfusion in pathological conditions.

View Article and Find Full Text PDF

: Cardiac surgery is associated with various durations of cerebral autoregulation (CA) impairment and can significantly impact cognitive function. Cognitive functions such as memory, psychomotor speed, and attention are significantly impacted after cardiac surgery, necessitating prioritization of these areas in cognitive function tests. There is a lack of research connecting cerebral autoregulation impairment to specific cognitive function domains after cardiac surgery.

View Article and Find Full Text PDF

Background: Subarachnoid hemorrhage (SAH) patients with cerebral autoregulation (CA) impairment at an early post-SAH period are at high risk of unfavorable outcomes due to delayed cerebral ischemia (DCI) or other complications. Limited evidence exists for an association between early-stage CA impairments and SAH patient outcomes. The objective of this prospective study was to explore associations between CA impairments detected in early post-SAH snapshot examinations and patient outcomes.

View Article and Find Full Text PDF
Article Synopsis
  • Optimal cerebral perfusion pressure (CPPopt) treatment for traumatic brain injury (TBI) patients requires collecting multi-modal monitoring data for 2-8 hours to determine individual CPPopt values.
  • A study analyzed data from 87 severe TBI patients to improve algorithms for identifying CPPopt, ABPopt (arterial blood pressure), ICPopt (intracranial pressure), and cerebrovascular autoregulation limits.
  • Machine learning algorithms were developed that accurately identify useful data segments within 24 minutes, improving the identification of optimal values and management strategies for 79% of the monitoring time, but further clinical studies are needed to validate their effectiveness.
View Article and Find Full Text PDF

Identification of individual therapy targets is critical for traumatic brain injury (TBI) patients. Clinical outcomes depend on cerebrovascular autoregulation (CA) impairment. Here, we compare the effectiveness of optimal cerebral perfusion pressure (CPPopt)-targeted therapy in younger (<45 years of age) and elderly (≥45 years of age) TBI patients.

View Article and Find Full Text PDF