and Study: COX-2 Inhibition by Ethanol Extract of Dayak Onion Bulb ( Merr) as Treatment Innovation of Benign Prostatic Hyperplasia (BPH).

Introduction: Benign Prostatic Hyperplasia (BPH) is a benign tumor in males, which is histopathologically known with an increase of epithelial cells and prostatic stroma. Androgens, estrogens, stroma-epithelial interactions, growth factors, and chronic inflammation play a key role in the occurrence of BPH. Chronic inflammation in BPH is characterized by excessive expression of COX-2, which will trigger the expression of Bcl-2 anti-apoptotic protein.