Trends in Specific Family Refusals for Pediatric Organ and Tissue Donation: A Cross-Sectional Study.

Background: When a family decides to donate the organs or tissues of their child with brain death, it is necessary to consider which organs or tissues will be donated. This phenomenon presents an ethical dilemma that is underexplored in the scientific literature, making it essential to examine this context to understand how refusals occur within donations.

Objective: To analyze the rates and trends of specific refusals for each organ and tissue from pediatric donors with brain death occurring between 2001 and 2020 in an Organ Procurement Organization in the State of São Paulo, Brazil.

Family refusal of skin donation for transplantation: trends and associated factors.

Objectives: to analyze the trends and factors associated with family refusal of skin donation for transplantation.

Methods: this cross-sectional study was conducted in the State of São Paulo, with family authorization terms collected from 2001 to 2020. The variables analyzed included year, age, gender, cause of death, and type of institution.

Immunomodulatory response in an experimental model of brain death.

Liver transplantation has come a long way and is now regarded as the gold standard treatment for end-stage liver failure. The great majority of livers utilized in transplantation come from brain-dead donors. A broad inflammatory response characterizes BD, resulting in multiorgan damage.

Thalidomide modulates renal inflammation induced by brain death experimental model.

Background: Brain death (BD) is characterized by a complex inflammatory response, resulting in dysfunction of potentially transplantable organs. This process is modulated by cytokines, which amplify graft immunogenicity. We have investigated the inflammatory response in an animal model of BD and analyzed the effects of thalidomide, a drug with powerful immunomodulatory properties.

Immunomodulatory effects of thalidomide in an experimental brain death liver donor model.

Brain death is characterized by a generalized inflammatory response that results in multiorgan damage. This process is mainly mediated through cytokines, which amplify graft immunogenicity. We investigated the immunological response in a brain death liver donor model and analysed the effects of thalidomide, a drug with powerful immunomodulatory properties.

Experiences and expectations of nurses in caring for organ donors and their families.

Objective Understand the experiences and expectations of intensive care unit nurses in caring for organ donors and their families. Method Qualitative research, with a social phenomenological approach, conducted in 2013 with 20 nurses. Results The experiences of the nurses with the families of donors were represented by two categories: obstacles encountered and interventions performed in the care of the donors' families.

Experience of nurses in the process of donation of organs and tissues for transplant.

Objective: to investigate the meaning of the action of nurses in the donation process to maintain the viability of organs and tissues for transplantation.

Method: this qualitative study with a social phenomenological approach was conducted through individual interviews with ten nurses of three Organ and Tissue Procurement Services of the city of São Paulo.

Results: the experience of the nurses in the donation process was represented by the categories: obstacles experienced in the donation process, and interventions performed.

The profile of potential organ and tissue donors.

This study aimed to characterize donors according to gender, age group, cause of brain death; quantify donors with hypernatremia, hyperpotassemia and hypopotassemia; and get to know which organs were the most used in transplantations. This quantitative, descriptive, exploratory and retrospective study was performed at the Organ Procurement Organization of the University of São Paulo Medical School Hospital das Clínicas. Data from the medical records of 187 potential donors were analyzed.

Family refusal to donate organs and tissue for transplantation.

This study aimed to discover how potential eligible donor families perceive the decision-making process to refuse organ and tissue donation for transplantation. A qualitative research was performed in order to understand the families' perception, based on the situated-phenomenon structure. Eight family members were interviewed, with four themes and fourteen subthemes emerging from the analysis of the statements.