Publications by authors named "Eduardo Verissimo"
Neurons have a unique polarized nature that must adapt to environmental changes throughout their lifespan. During embryonic development, axon elongation is led by the growth cone, culminating in the formation of a presynaptic terminal. After synapses are formed, axons elongate in a growth cone-independent manner to accompany body growth while maintaining their ultrastructure and function.
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- NOX2 has been linked to neuropathic pain (NP) through its role in neuroinflammation, and this study examined the effects of a NOX2 inhibitor on NP in male and female mice.
- Early treatment with the NOX2-selective inhibitor GSK2795039 reduced pain hypersensitivity and microglial activation in both sexes.
- While the treatment affected anxiety-like behaviors and certain inflammatory markers differently in males and females, it suggests that targeting NOX2 could be a viable strategy for managing NP, particularly with benefits noted for females.