Publications by authors named "Eduardo Talamo"
Background: The antipsychotic drug (APD) clozapine (CLZ) is under-prescribed because of concerns about its safety. We evaluated in separate protocols the frequency of cardiomyopathy and hyponatraemia, which are adverse drug effects, where few comparative studies are available.
Methods: Cross-sectional studies in subjects treated for at least 3 consecutive months with the same drug were conducted.
Article Synopsis
- Excessive bodyweight gain has been a known side effect of antipsychotic medications since the 1950s, but newer atypical antipsychotics, particularly clozapine and olanzapine, cause more significant weight increases compared to older drugs.
- In clinical studies, notable differences in weight gain percentages were observed among various antipsychotics, with olanzapine showing the highest risk for >7% weight gain.
- A combination of dietary changes, exercise, and potential medication adjustments are suggested for managing this side effect, but more comprehensive studies are needed to establish effective long-term solutions.