Publications by authors named "Eduardo T Fernandes"
Obesity is characterized by the accumulation of dysfunctional adipose tissues, which predisposes to cardiometabolic diseases. Our previous in vitro studies demonstrated a role of hypoxia in inducing adipokine hypomethylation in adipocytes. We sought to examine this mechanism in visceral adipose tissues (VATs) from obese individuals and its correlation with cardiometabolic risk factors.
View Article and Find Full Text PDFBackground: Immune cells (lymphocytes and macrophages) provide the microenvironment for immune surveillance of metastatic prostate cancer (PCa) cells in pelvic lymph nodes. We have hypothesized that degeneration and/or apoptosis of metastatic PCa cells in pelvic lymph nodes can distinguish between aggressive and non-aggressive metastatic disease in patients. Our objective was to define the relationship between metastatic cell lysis and the presence of immune cells.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of cathepsin B, a protease, in the invasiveness of prostate cancer in U.S. African-American and Caucasian men.
- Despite expectations of greater cancer invasiveness in African-American men, the results show no significant difference in cathepsin B levels between races.
- This led to the conclusion that prostate cancer invasiveness does not depend on race, prompting a reevaluation of previous assumptions regarding race-based differences in prostate cancer aggressiveness.
Background: Pathologic grade and/or histologic score, extraprostatic extension indicated by invasion of the prostatic capsule, margin, and/or seminal vesicles by prostate cancer cells, serum total prostate-specific antigen (PSA), free PSA, complexed PSA levels and/or their ratios, regional pelvic lymph node metastases, and clinical staging have been used to diagnose and monitor the treatment of prostate carcinoma (PC) patients. The Gleason grading system is also used to grade/score a patient's stage of disease, with lower to higher scores indicating progression of PC. However, Gleason's system cannot be used to distinguish biologically aggressive PCs within a single Gleason score.
View Article and Find Full Text PDFObjectives: To evaluate the need for routine biopsy at first follow-up after intravesical bacille Calmette-Guérin (BCG) therapy for superficial transitional cell cancer of the bladder (TCCB). We examined the potential role of voided urine cytology and cystoscopy as screening tools to determine which patients should undergo biopsy.
Methods: The records of 71 patients with TCCB who received a total of 95 courses of BCG were reviewed.