Dlg Is Required for Short-Term Memory and Interacts with NMDAR in the Brain.

The vertebrates' scaffold proteins of the Dlg-MAGUK family are involved in the recruitment, clustering, and anchoring of glutamate receptors to the postsynaptic density, particularly the NMDA subtype glutamate-receptors (NRs), necessary for long-term memory and LTP. In , the only gene of the subfamily generates two main products, , broadly expressed, and , restricted to the nervous system. In the brain, NRs are expressed in the adult brain and are involved in memory, however, the role of Dlg in these processes and its relationship with NRs has been scarcely explored.