Publications by Eduardo Pernaut-Leza

Publications by authors named "Eduardo Pernaut-Leza"

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A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype.

Amarnath Pal Jennifer C Ashworth Pamela Collier Catherine Probert Sal Jones

Cancers (Basel)

August 2020

Article Synopsis

Mesenchymal stem cells (MSCs) enhance breast cancer cell (BCC) proliferation and promote cancer progression through paracrine signaling in a 3D co-culture model.
Co-culture leads to decreased E-cadherin levels and increased SNAIL expression, indicating a shift towards epithelial-mesenchymal transition (EMT).
The study suggests that SnON may serve as a biomarker for breast cancer invasiveness, pointing to the interaction between TGF-β and Wnt signaling as potential therapeutic targets.

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Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.

Idoia Blanco-Luquin Rosa Guarch Amaya Ojer Noemí Pérez-Janices Esperanza Martín-Sánchez Eduardo Pernaut-Leza

Pathol Int

September 2015

Cervical cancer is the third most common cancer in women worldwide. The hypermethylation of P16, TSLC-1 and TSP-1 genes was analyzed in squamous cell carcinomas (SCC), cervical intraepithelial lesions (CIN) and adenocarcinomas (ADC) of the uterine cervix (total 181 lesions). Additionally human papillomavirus (HPV) type, EPB41L3, RASSF1 and RASSF2 hypermethylation were tested in ADC and the results were compared with those obtained previously by our group in SCC.

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