Publications by authors named "Eduardo Martin-Nares"
Objectives: To assess work history, occupational exposure, smoking, and biomass fuel use in a Mexican IgG4-related disease (IgG4-RD) cohort.
Methods: We conducted a cross-sectional study among patients with IgG4-RD. A standardised questionnaire was used to collect data on occupational, smoking, and biomass fuel exposure.
Article Synopsis
- Dry eye disease (DED) may be associated with axial spondylarthritis (axial-SpA), as this study aims to investigate the correlation between the two conditions and identify related variables.
- Out of 71 axial-SpA patients, 64.8% reported DED symptoms compared to only 15.8% of 19 healthy controls, suggesting a significantly higher prevalence of DED in axial-SpA patients.
- Various ocular tests revealed that axial-SpA patients exhibited poorer tear production and ocular surface health, indicated by lower Schirmer test scores, shorter tear break-up times, and higher staining levels, reinforcing the link between axial-SpA and DED.
Objective: The objective is to assess the performance of the 2023 American College of Rheumatology/EULAR classification criteria (2023 AECC) for antiphospholipid syndrome (APS) in a Mexican cohort.
Methods: We enrolled patients with primary APS (PAPS) and secondary APS (SAPS) and a control group of nonautoimmune thrombophilia. We evaluated the fulfillment of the 2023 AECC and the 2006 revised Sapporo classification criteria (2006 RSCC) and their performance against the clinical diagnosis as the gold standard.
Autoimmunity in patients with inborn errors of immunity: A case series.
Reumatol Clin (Engl Ed)
August 2024
Objective: To assess the prevalence of systemic and organ-specific autoimmunity among individuals with human inborn errors of immunity (IEI).
Methods: Retrospective study. We recorded demographic variables, type of immunodeficiency, and systemic and organ specific autoimmunity.
Article Synopsis
- The study aimed to assess if the amount of IgG4+ plasma cells in biopsies affects clinical and serological outcomes in patients with IgG4-related disease (IgG4-RD).
- It included 57 patients and recorded various clinical and histological data, revealing that higher counts of IgG4+ plasma cells are linked to certain disease phenotypes and better clinical outcomes.
- A count of 100 or more IgG4+ plasma cells per high-power field was associated with fewer relapses and a higher chance of remission, indicating its potential as a useful diagnostic indicator.
Objectives: Integrating clinical and histological parameters into prognostic scores may enhance the prediction of progression to kidney failure in anti-neutrophil cytoplasm antibodies-associated vasculitis (AAV). This study aimed to evaluate the prognostic performance of histological classifications and scoring systems for kidney survival in AAV.
Methods: This retrospective cohort study included 101 AAV patients with kidney involvement diagnosed by biopsy and followed for ≥12 months.
Article Synopsis
- The study investigates the relationship between Familial Mediterranean fever (FMF), a severe inflammatory condition, and the risk of cancer development compared to other diseases like fibromyalgia, Still's disease, and Behçet's disease.
- Results show that FMF patients have a significantly lower risk for malignancies compared to fibromyalgia patients, with a risk ratio (RR) of 0.26; however, this risk is less clear when comparing with the other conditions.
- Factors influencing cancer risk in FMF patients include age at onset and diagnosis, frequency of disease attacks, and treatment with specific biotechnological agents.
Article Synopsis
- - The study aimed to analyze the clinical and radiological characteristics and outcomes of 74 patients diagnosed with hypertrophic pachymeningitis (HP) at a single center over nearly two decades.
- - Among patients, 43.2% had immune-mediated origins, notably granulomatosis with polyangiitis (GPA), while 56.8% had non-immune-mediated HP, including infectious cases like TB and malignancy-associated HP.
- - The findings revealed notable differences in MRI features and clinical presentations across the various causes of HP, highlighting GPA and Mycobacterium tuberculosis as the main culprits, potentially aiding in more accurate diagnoses.
Article Synopsis
- - VEXAS syndrome is a new autoinflammatory disease that often affects various organs, with noticeable inflammatory issues in the eyes and orbits.
- - In a study of 59 VEXAS patients, 45.8% exhibited orbital/ocular problems, with periorbital edema and episcleritis being the most common conditions observed.
- - There is a significant link between relapsing polychondritis and eye involvement in VEXAS, and patients with eye issues showed higher mortality rates, indicating the need for closer monitoring by healthcare providers.
Article Synopsis
- This study evaluated the effectiveness of a systemic score in predicting severe outcomes in patients with Still disease, including the risk of mortality and severe complications like macrophage activation syndrome.
- Involving 597 patients, the study found that a higher systemic score significantly correlated with life-threatening outcomes, with scores of 7 or above indicating a greater risk.
- Key components that were most predictive of severe outcomes included liver and lung involvement, emphasizing the importance of these factors in managing Still disease.
We present an intriguing case involving a rare occurrence of sclerosing angiomatoid nodular transformation (SANT) in a 57-year-old woman with a history of granulomatosis with polyangiitis (GPA). Despite the extensive literature on SANT, its pathogenesis remains elusive. The patient, diagnosed with serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA)-positive GPA seven years earlier, exhibited a splenic lesion during imaging, leading to laparoscopic splenectomy due to severe abdominal pain.
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- The study gathered data on 358 patients with polyarteritis nodosa (PAN) from nine countries, analyzing demographics, clinical features, and survival rates over 30 years.
- Findings showed common symptoms such as constitutional issues, skin lesions, joint pain, and neurological problems, with a significant relapse rate of 48.5% during an average follow-up of nearly five years.
- Survival rates for systemic PAN showed a decline over time, with important risk factors for mortality including older age, high serum creatinine levels, and involvement of the gastrointestinal system or central nervous system.
Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort.
J Clin Rheumatol
March 2024
Article Synopsis
- The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is a promising development, but previous studies primarily focused on White and Asian populations, highlighting the need for research in Latin America.
- A study collected medical records from 300 patients across multiple Latin American countries, finding that 66.7% of IgG4-RD cases were accurately identified by the 2019 AECC, with specificity reaching 100%.
- Although the criteria were effective in identifying true cases, the presence of other autoimmune diseases and certain autoantibodies limited its sensitivity, suggesting the criteria may exclude some patients who actually
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is an adult-onset autoinflammatory syndrome characterized by somatic mutations in the UBA1 gene and is considered the prototype of hematoinflammatory diseases. Patients with VEXAS syndrome exhibit inflammatory and hematological manifestations that can lead to clinical diagnoses such as relapsing polychondritis, polyarteritis nodosa, Sweet syndrome, and myelodysplastic syndrome. Diagnosis requires bone marrow evaluation to identify cytoplasmic vacuoles in myeloid and erythroid precursors.
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- - This study investigates whether pediatric-onset, adult-onset, and elderly-onset Still's disease are the same condition or different diseases by comparing demographic, clinical, and treatment response data across these age groups.
- - Out of 411 patients surveyed, most were adults (76.4%), while 15.8% were pediatric and 7.8% were elderly, with significant differences found in symptoms like skin rash and arthritis being more prevalent in children, and pleuritis in the elderly.
- - Overall, while some minor differences in symptoms and lab results were noted among the age groups, the study concludes that Still's disease has similar demographic and treatment characteristics across pediatric, adult, and elderly patients.
Article Synopsis
- The study focuses on patients with Still's disease to identify clinical and laboratory signs associated with macrophage activation syndrome (MAS), a serious complication.
- Out of 414 patients examined, 39 (9.4%) developed MAS, with several significant variables like liver involvement and high ferritin levels linked to its occurrence.
- Multivariate analysis revealed that having hepatomegaly and monoarthritis were directly associated with MAS, while factors like a normal platelet count were protective against its development.