Publications by authors named "Eduardo M Acevedo-Vasquez"
Article Synopsis
- - The study investigates the characteristics and effects of the time taken to diagnose systemic lupus erythematosus (SLE) in a Latin American cohort, noting that diagnosis can often be delayed and that SLE may resemble other diseases.
- - Patients with longer diagnosis times (over 6 months) were often older, female, of Mestizo descent, uninsured, and displayed atypical symptoms, but this delayed diagnosis did not seem to affect their disease progression or mortality rates significantly.
- - Overall, the research concludes that within this cohort, waiting up to 24 months for an SLE diagnosis, with a median of 6 months, did not lead to worse health outcomes.
Article Synopsis
- The study investigates factors influencing neuropsychiatric (NP) manifestations in patients with newly diagnosed Systemic Lupus Erythematosus (SLE), aiming to identify both disease-related and demographic factors.
- A total of 1,193 patients without NP involvement at the start were analyzed using clinical and lab data, applying a multivariable regression model to find independent risk factors.
- Key findings highlight that certain conditions like myalgias, pneumonitis, and hemolytic anemia increase the risk of NP involvement, while longer disease duration at the start is linked to a lower risk.
Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE).
Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone.
Article Synopsis
- * A study was conducted by rheumatologists and methodologists, leading to the formulation of guidelines addressing common clinical issues faced by SLE patients in the region, based on best available evidence.
- * The guidelines cover nine organ/system sections, focusing on pharmacological treatments, their benefits and risks, and emphasize regional implementation, considering ethnic and socioeconomic factors.
Objective: To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America.
Methods: Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform.
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P<5 × 10), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect.
View Article and Find Full Text PDFObjective: To identify susceptibility loci for rheumatoid arthritis (RA) in Latin American individuals with admixed European and Amerindian genetic ancestry.
Methods: Genotyping was performed in 1,475 patients with RA and 1,213 control subjects, using a customized BeadArray containing 196,524 markers covering loci previously associated with various autoimmune diseases. Principal components analysis (EigenSoft package) and Structure software were used to identify outliers and define the population substructure.
Article Synopsis
- The study aimed to assess how socioeconomic factors influence disease activity in early rheumatoid arthritis patients from Latin America.
- The research involved evaluating clinical data from 1,093 patients, analyzing variables such as age, sex, education, and medical coverage impact on disease severity and disability.
- Key findings revealed that low socioeconomic status, female gender, and lack of medical coverage were linked to poorer health outcomes, with significant variations in disease activity observed across different countries and ethnic groups.
To evaluate disease characteristics of childhood onset SLE in Latin America and to compare this information with an adult population in the same cohort of GLADEL. A protocol was designed as a multicenter, multinational, inception cohort of lupus patients to evaluate demographic, clinical, laboratory and serological variables, as well as classification criteria, disease activity, organ damage and mortality. Descriptive statistics, chi square, Fisher's exact test, Student's t test and multiple logistic regression were used to compare childhood and adult onset SLE.
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