Bile Acids as Signaling Molecules: Role of Ursodeoxycholic Acid in Cholestatic Liver Disease.

Ursodeoxycholic acid (UDCA) is a natural substance physiologically produced in the liver. Initially used to dissolve gallstones, it is now successfully used in treating primary biliary cirrhosis and as adjuvant therapy for various hepatobiliary cholestatic diseases. However, the mechanisms underlying its beneficial effects still need to be clarified.

Characterization of strength, endurance and lung function in subjects with neuromuscular diseases with the R577X polymorphism of the ACTN3 gene.

Unlabelled: The ACTN3 R577X polymorphism determines the expression of alpha-actinin 3 protein in human muscle. The homozygous XX genotype fails to synthesize alpha-actinin 3 and is associated with lower muscle strength than the RR genotype. Neuromuscular diseases (NMD) generate an accelerated loss of muscle strength, and their relationship with the ACTN3 gene has not been established.

[Hospitalary concurrent exercise program in overweight and obese school students and adolescents during COVID-19 pandemic].

Unlabelled: The COVID-19 pandemic reduced daily physical activity in the pediatric population, with deleterious effects on anthropometry, muscle function, aerobic capacity, and metabolic control.

Objective: Determine the changes in anthropometry, aerobic capacity, muscle function, and metabolic control of a 12-week concurrent training protocol in overweight and obese children and adolescents during the COVID-19 pandemic.

Patients And Method: 24 patients participated and were divided into groups once a week (12S; n = 10) and twice a week (24S; n = 14).

Differential Fibrotic Response of Muscle Fibroblasts, Myoblasts, and Myotubes to Cholic and Deoxycholic Acids.

Fibrosis is a condition characterized by an increase in the components of the extracellular matrix (ECM). In skeletal muscle, the cells that participate in the synthesis of ECM are fibroblasts, myoblasts, and myotubes. These cells respond to soluble factors that increase ECM.

Impact of a Community-Based Pelvic Floor Kinesic Rehabilitation Program on the Quality of Life of Chilean Adult Women with Urinary Incontinence.

Unlabelled: The pelvic floor forms the primary bottom tissue of the pelvic cavity. It comprises muscles that play a fundamental role in bowel and bladder emptying. Alterations of pelvic floor muscles will result in dysfunctions such as urinary incontinence (UI).

[Effect of a 12-week concurrent planification exercise program in overweight and obese children and adolescents].

Objective: To determine the changes in a planned concurrent exercise protocol in overweight and obese children and adolescents who attend a cardiometabolic rehabilitation program at the Dr. Exequiel González Cortés hospital.

Patients And Method: 32 patients were divided into two groups, the intervention group (INT) (n = 22; age: 12.

[Evaluation and follow-up in functionality in patients with Pediatric Multisystem Inflammatory Syndrome associated with COVID-19 (MIS-C)].

Unlabelled: In June 2020 appeared the first cases of Multisystem Inflammatory Syndrome in Children (MIS C) associated with COVID-19 in Chile. Possible sequelae associated with this condition are still unknown.

Objective: To describe the functional status of children with MIS-C admitted to a high complexity Hospital.