Intrahippocampal anisomycin infusions disrupt previously consolidated spatial memory only when memory is updated.

Reconsolidation has proven to be a common phenomenon relevant to memory processing. However, the functional significance of this process is still a matter of debate. Previous work has shown that reconsolidation is indeed a process by which updated information is integrated, through the synthesis of proteins, to a memory trace.

Effects of phosphorylation and cytoskeleton-affecting reagents on GABA(A) receptor recruitment into synaptosomes following acute stress.

The [3H]-flunitrazepam receptor density, measured ex vivo in synaptosomes at 4 degrees C, increased by about 30% because of acute stress in chicks. This increase was first reported to be a receptor recruitment due to the fact that the increase induced by subsolubilizing concentrations of Triton X-100 was not additive to the receptor increase induced by acute stress [J Neural Transm 87 (1992) 97]. In synaptosomal membranes from stressed chicks, the incorporation of alkaline phosphatase or ATP into the lumen abolished or increased, respectively, the receptor unmasking after incubation at 4 and 37 degrees C, suggesting that phosphorylation plays a role in the recruitment mechanism.