Publications by authors named "Eduard van Hagen"
Article Synopsis
- There has been a notable rise in research and knowledge about the coronary microcirculation over the last 20 years, despite these small vessels being invisible to the naked eye.
- Current measurement techniques for these vessels, like coronary flow reserve (CFR) and index of microvascular resistance (IMR), depend on the operator and require adenosine to enhance blood flow.
- A new thermodilution-based method using the Rayflow infusion catheter and Coroventis software has emerged, offering an accurate and operator-independent way to measure absolute coronary blood flow and resistance, validated against PET-CT and proven safe over the long term.
Aims: Hypothermia reduces reperfusion injury and infarct size in animal models of acute myocardial infarction if started before reperfusion. Human studies have not confirmed benefit, probably due to insufficient myocardial cooling and adverse systemic effects. This study sought to assess the safety and feasibility of a novel method for selective, sensor-monitored intracoronary hypothermia.
View Article and Find Full Text PDFObjectives: This study sought to validate a new method for direct volumetric blood flow measurement in coronary arteries in animals and in conscious humans during cardiac catheterization.
Background: Direct volumetric measurement of blood flow in selective coronary arteries would be useful for studying the coronary circulation.
Methods: Based on the principle of thermodilution with continuous low-rate infusion of saline at room temperature, we designed an instrumental setup for direct flow measurement during cardiac catheterization.