Publications by authors named "Eduard Jezo"
Article Synopsis
- The study compares two tests that measure cellular immunity against SARS-CoV-2: Quan-T-Cell by EUROIMMUN and T-SPOT.COVID by Oxford Immunotec, focusing on 90 individuals with past COVID-19 infections or vaccinations.
- Both tests showed similar results, but Quan-T-Cell was slightly more sensitive, identifying all individuals as at least borderline positive, while T-SPOT.COVID missed five.
- The findings suggest that measuring T-cell-mediated immunity may be a more reliable indicator of the immune response than examining IgG levels, especially in unvaccinated individuals previously infected with the Omicron variant.
Article Synopsis
- Elderly nursing home residents show a robust immune response to SARS-CoV-2 vaccines, with 95.2% testing positive for IgG antibodies and high rates of virus neutralization against the Delta variant.
- Convalescent residents, those who had previous COVID-19 infections, exhibit significantly stronger immune responses than naive residents after vaccination.
- The study highlights the need for tailored booster strategies, particularly for vaccinated residents with hybrid immunity, as they appear to have better protection against COVID-19.
Many studies reported good performance of nasopharyngeal swab-based antigen tests for detecting SARS-CoV-2-positive individuals; however, studies independently evaluating the quality of antigen tests utilizing anterior nasal swabs or saliva swabs are still rare, although such tests are widely used for mass testing. In our study, sensitivities, specificities and predictive values of seven antigen tests for detection of SARS-CoV-2 (one using nasopharyngeal swabs, two using anterior nasal swabs and four using saliva) were evaluated. In a setting of a high-capacity testing center, nasopharyngeal swabs for quantitative PCR (qPCR) were taken and, at the same time, antigen testing was performed in accordance with manufacturers' instructions for the respective tests.
View Article and Find Full Text PDFCovid-19 antigen testing: better than we know? A test accuracy study.
Infect Dis (Lond)
September 2021
Background: Antigen testing for SARS-CoV-2 is considered to be less sensitive than the standard reference method - real-time PCR (RT-PCR). It has been suggested that many patients with positive RT-PCR 'missed' by antigen testing might be non-infectious.
Methods: In a real-world high-throughput setting for asymptomatic or mildly symptomatic patients, 494 patients were tested using RT-PCR as well as a single lateral flow antigen test (Ecotest, AssureTech, China).
Antigen testing for SARS-CoV-2 (AGT) is generally considered inferior to RT-PCR testing in terms of sensitivity. However, little is known about the infectiousness of RT-PCR positive patients who pass undetected by AGT. In a screening setting for mildly symptomatic or asymptomatic patients with high COVID-19 prevalence (30-40%), 1141 patients were tested using one of five AGTs and RT-PCR.
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