Publications by authors named "Edsel A Abud"
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Acta Neuropathol Commun
June 2016
Article Synopsis
- Alzheimer's disease is marked by β-amyloid plaques and tau tangles, and new studies indicate that protein aggregation and inflammation are interconnected in neurodegeneration.
- A new transgenic mouse model, called T5x, shows that while tau pathology increases significantly due to Aβ interaction, the actual Aβ plaque load decreases, which is unexpected.
- This model reveals changes in microglial activity, including increased numbers and enhanced ability to clear Aβ, suggesting potential therapeutic strategies to boost microglial function for reducing plaque accumulation.