Peroxiredoxin 6 Peroxidase and Ca-Independent Phospholipase A Activities Are Essential to Support Male-Mouse Fertility.

Human infertility is an important health problem that affects one in six couples worldwide. Half of these cases are due to male infertility. Oxidative stress is a common culprit of male infertility, promoting lipid peroxidation and the oxidation of proteins and DNA in spermatozoa, thereby impairing motility, capacitation and fertilization.