Publications by authors named "Edouard Hallet"
Background: A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women than in non-precarious pregnant women, as reflected by their health insurance status.
Methods: A multicentric cross-sectional study was conducted in Cayenne hospital including ZIKV pregnant women with serological or molecular proof of ZIKV during their pregnancy between January and December 2016.
Background: Given the great efforts put into the strategic objective of reducing the proportion of HIV-infected patients that are undiagnosed, the aim of the present study was to review the temporal trends between 1997 and 2016 for median estimates of infection duration and median CD4 count at diagnosis for the main patient origins in French Guiana.
Methods: CD4 cell count at HIV sero-conversion and square root of CD4 cell decline were obtained using the CD4 decline in a cohort of HIV-infected persons in the UK, fitting random effect (slope and intercept) multilevel linear regression models. Multivariate analysis used robust regression for modeling the delay between estimated HIV seroconversion and diagnosis and quantile regression for CD4 at HIV diagnosis.
Article Synopsis
- A significant Zika virus outbreak occurred in French Guiana and the West Indies from January to October 2016, with 1650 pregnant women affected.
- ZIKV infection during pregnancy is linked to serious birth defects like microcephaly, but in this case, two children born from mothers with symptomatic infections showed no immediate abnormalities at birth.
- Despite initial healthy appearances, both children later exhibited severe brain abnormalities related to in utero ZIKV exposure detected through MRI, suggesting potential implications of the mother's immune response or metabolic changes during infection.