Nanostructural diversity: self-assembly of isomeric pyrene-cholane amphiphiles into sheets, tubes, and worm-like morphologies.

Phosphodiester-linked cholane-pyrene-cholane trimers self-assemble into sheet-, tube- and worm-like nanostructures in aqueous conditions. The nanotubes and worm-like assemblies exist as single- or multi-walled objects.

Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer.

Macrocyclic compounds are an attractive class of therapeutic ligands against challenging targets, such as protein-protein interactions. However, the development of macrocycles as drugs is hindered by the lack of large combinatorial macrocyclic libraries, which are cumbersome, expensive, and time consuming to make, screen, and deconvolute. Here, we established a strategy for synthesizing and screening combinatorial libraries on a picomolar scale by using acoustic droplet ejection to combine building blocks at nanoliter volumes, which reduced the reaction volumes, reagent consumption, and synthesis time.