Publications by authors named "Edoardo Pasqui"
Article Synopsis
- - The study evaluated the geometrical effects of three different carotid stents on the carotid bifurcation in patients who underwent carotid artery stenting (CAS), revealing variations in anatomical changes after stent placement.
- - A total of 226 patients were analyzed, showing the Roadsaver stent resulted in a greater change in the angle between common carotid artery (CCA) and internal carotid artery (ICA) compared to the other two stents, but this did not significantly affect the rate of restenosis.
- - Overall, the Roadsaver stent's lower adaptability to the carotid vascular area suggests it might cause more pronounced angulations post-implantation, while the Carotid Wallstent and C
Background: The comorbidity-polypharmacy score (CPPS) was created to evaluate the clinical burden of comorbidities in geriatric patients. It represents an objective tool to stratify patients' risk in different settings. The study aimed to evaluate CPPS in predicting mortality and amputation in patients undergoing elective revascularization procedures in chronic limb-threatening ischemia (CLTI) patients.
View Article and Find Full Text PDFBackground: Lung cancer and aortic disease share multiple risk factors. The co-presence of both diseases defines a peculiar type of patient who needs a specific protocol of treatment and follow-up. The aim of our study was to evaluate the prevalence of aortic disease in a population of patients with a diagnosis of primary lung cancer.
View Article and Find Full Text PDFPurpose: To perform a qualitative systematic review of endovascular management of renal artery aneurysms (RAAs).
Materials And Methods: A comprehensive electronic search of PubMed, MEDLINE, Embase, Google Scholar, and Cochrane databases from 2000 to 2022 was performed using the search terms "renal artery," "aneurysm," and "endovascular." Means of outcome measures were calculated with a primary end point focused on RAA-related mortality and rupture.
Article Synopsis
- The study aimed to develop a predictive model (STRESS score) to identify high-risk patients for postoperative delirium (POD) following elective vascular surgery.
- An observational retrospective analysis was conducted on 1,067 patients, finding a 10.4% incidence of POD, with significant risk factors identified through logistic regression.
- The STRESS score demonstrated solid predictive ability for POD in the study groups, but further validation is required for clinical implementation.
Article Synopsis
- - The study aimed to explore the link between apical periodontitis (AP) and atherosclerotic cardiovascular disease (ASCVD) in 65 patients aged 40 and older, assessing their dental health and cardiovascular conditions.
- - Results showed that over half of the patients with AP (57.58%) exhibited signs of subclinical carotid atherosclerosis, with multiple regression analysis indicating that AP significantly increased the risk of carotid plaques and thickening of the carotid artery walls.
- - The findings suggest that AP could serve as an important risk indicator for ASCVD, demonstrating a 5-fold and 15-fold higher risk for carotid plaques and marked intima-media thickness, respectively, though other dental health measures
Introduction: In this study, we evaluated the role of preoperative inflammatory markers as Neutrophil-to-Lymphocyte (NLR) and Platelet-to-Lymphocyte (PLR) ratios in relation to post-endovascular aneurysm repair (EVAR) sac shrinkage, which is known to be an important factor for abdominal aortic aneurysm (AAA) healing.
Methods: This was a single-center retrospective observational study. All patients who underwent the EVAR procedure from January 2017 to December 2020 were eligible for this study.
Article Synopsis
- Effective anticoagulation is crucial for endovascular procedures to prevent thrombo-embolic complications caused by device manipulation.
- There is a lack of clear evidence on the optimal use and monitoring of anticoagulant medications in peripheral arterial procedures, even though systemic heparinization is common.
- Patient-specific factors and procedure details must be considered when deciding how to manage anticoagulation and monitor coagulative status throughout vascular procedures.
Endovascular thrombectomy devices for acute limb ischemia management.
J Cardiovasc Surg (Torino)
June 2023
Acute limb ischemia still represents a challenge for the contemporary vascular surgeon, representing an immediate threat for patients' limb but potentially also for the proper patient life in some settings. Technology recently evolved and focused on the treatment of such complex situation. Several devices are available as of today allowing a complete acute limb ischemia endovascular management, aiming to remove intraluminal material while leaving the possibility for treating the underlying pathology when needed.
View Article and Find Full Text PDFArticle Synopsis
- - The study assessed the safety and effectiveness of the Penumbra Indigo thrombectomy system for treating iliac limb occlusion (ILO) after endovascular aortic repair (EVAR) across eight vascular centers in Italy.
- - Involving 17 patients with a median age of 75, the results showed an 82% technical success rate after the initial procedure, with a combined success of 94% when adjunctive treatments were included.
- - Follow-up findings indicated no recurrence of ILO in patients over one year, with only one case of 30-day mortality attributed to pneumonia, highlighting both the safety and effectiveness of the treatment.
Background: Penumbra/Indigo aspiration thrombectomy Systems (Penumbra Inc.) in patients with acute lower limb ischemia (ALLI) is becoming a fundamental alternative to surgical and intra-arterial thrombolysis. The INDIAN UP trial represents the second phase of the Italian national multicenter trial evaluating the safety and effectiveness of the device in the treatment of ALLI.
View Article and Find Full Text PDF3D-printed model of simulation for acute thrombus removal in peripheral arteries.
J Cardiovasc Surg (Torino)
June 2023
Background: Surgical training and evaluation of medical devices require simulation models. The aim of this study was to assess a 3D-printed model as a training model for peripheral endovascular procedures, including thromboaspiration in acute limb ischemia (ALI).
Methods: The 3D-simulation model was modeled from an aorta and lower limbs CT scan by segmentation of the arterial light.
Article Synopsis
- A multicenter retrospective study evaluated the early results and mid-term effectiveness of self-expanding covered stenting for external iliac artery occlusive disease from 2015 to 2021, using the Viabahn stent.
- The study included 93 patients, primarily older males, with various conditions of limb discomfort and significant lesions; technical success was 100%, with a 1.4% perioperative death rate and 6.5% complications.
- Results showed an impressive 89.8% primary patency at an average follow-up of 42 months; severe calcifications and tortuosity didn't significantly affect outcomes, but stents less than 8 mm in diameter were linked to poorer patency rates.
Background: We present a standardized protocol of endovascular revascularization for patients with acute limb ischemia due to popliteal artery aneurysm (PAA) thromboembolic complication, based on the combination of vacuum-assisted thromboaspiration to improve tibiopedal outflow and covered stent graft to exclude the PAA.
Methods: All patients with a diagnosis of PAA complicated by thromboembolic events undergoing total endovascular rescue were prospectively enrolled in a dedicated database from November 2018 to November 2021. To assess vessel patency, the TIPI (Thromboaspiration In Peripheral Ischemia) classification was used.
Our aim was to determine the predictive role of the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in vascular access malfunctioning in patients who had undergone their first native arterio-venous fistula (AVF) for hemodialysis. Methods: This was a single-center retrospective observational study. All patients who underwent the procedure of the creation of a first native AVF for hemodialysis from January 2019 to December 2020 were considered eligible to be part of this study.
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- Post-operative delirium (POD) is a frequent issue in older patients after vascular surgery, affecting 11.3% of those studied, leading to longer hospital stays and more reinterventions.
- The research analyzed inflammatory markers (NLR, PLR, SII) against POD occurrence, finding that higher levels indicated a greater risk of developing delirium.
- Factors like age, renal failure, and specific surgical procedures were identified as independent risk factors, suggesting that these biomarkers could assist in predicting and managing POD in vascular surgery patients.
Article Synopsis
- The Ovation Abdominal Stent Graft System, including its redesigned version called Ovation Alto, provides a new sealing option for repairing abdominal aortic aneurysms (AAA), with CE Mark approval granted in August 2020 for the Alto model.
- This registry study aims to assess the outcomes of patients undergoing elective endovascular aneurysm repair (EVAR) using the Alto stent graft, with an estimated 300 participants across various centers over a 24-month enrollment period followed by a 5-year follow-up.
- Key goals include evaluating the technical and clinical success of the procedure as well as analyzing factors such as operative time, radiation exposure, and the impact of patient characteristics and device configuration on outcomes.
Introduction: Anomalies in inferior vena cava represent an uncommon finding with a prevalence of 0. 3 to 0.5% among healthy patients.
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- - Erectile dysfunction (ED) is the ongoing inability to achieve or maintain an erection suitable for sexual intercourse, and it shares common risk factors with cardiovascular diseases; however, its prevalence in patients with abdominal aortic aneurysm (AAA) is not well studied.
- - This study explored how well preoperative information on sexual function is communicated to patients undergoing endovascular aneurysm repair (EVAR), assessing ED through the International Index of Erectile Function questionnaire and comparing results with pelvic artery health indicated by preoperative CTA scans.
- - Out of 25 enrolled patients, the majority exhibited varying degrees of ED, with 80% showing moderate to severe pelvic arterial disease, demonstrating a significant relationship between the severity of pelvic vascular issues and the severity of
Article Synopsis
- The Ovation Alto endograft system, introduced after CE Mark approval in 2020, features a newly positioned sealing ring for improved endovascular aneurysm repair outcomes.
- In a study involving 11 male patients with an average age of 75, the procedures showed no complications, with successful technical results and minimal blood loss and procedure time.
- Follow-ups at one and six months revealed 100% clinical success, with no adverse events, indicating promising early results but highlighting the need for further research on long-term durability.
Asherson's Syndrome, also defined as Catastrophic Antiphospholipid Syndrome (CAPS), represents the most severe manifestation of Antiphospholipid Antibody Syndrome. Rarely, the first CAPS diagnosis is based on macro-thrombotic event as acute limb ischemia. We present a case of a 65-year-old woman admitted with an acute lower limb arterial ischemia with a complete occlusion of all the three tibial vessels.
View Article and Find Full Text PDFObjective: In recent years, manufacturers have developed new stent grafts with lower profiles to increase the endovascular aneurysm repair applicability. As reported by the current European Society for Vascular Surgery guidelines, long-term evaluation of such low-profile platforms is strongly recommended. This study aims to report outcomes beyond 5 years from a multicenter registry, including a real-world cohort of patients electively treated with low-profile stent grafts.
View Article and Find Full Text PDFIntoduction: Familial cerebral cavernous malformations (FCCM) are a rare condition characterized by the multiple presences of cavernous malformations located in the central nervous system.
Case Description: We present a case of FCCM incidental diagnosis in a 71-year-old male patient who underwent carotid artery stenting for high-grade carotid artery disease and subsequent reintervention for severe stent restenosis, determining neurological deficit. FCCM diagnosis was made due to the presence of hundreds of cavernous malformations located both in supra- and sub-tentorial regions highlighted by magnetic resonance and confirmed by genetic test for the mutation of the gene KRIT1, inherited also by his son.