Publications by authors named "Edoardo L M Gelardi"
Article Synopsis
- Glioblastoma (GBM) is a very dangerous brain tumor, and there isn't a good way to find or treat it early on.
- Researchers have created special fluorescent probes using curcumin that can specifically attach to a certain enzyme (ALDH1A3) found in glioma stem cells, helping to identify these tumor cells.
- These probes work well in recognizing GBM cells both in lab tests and in living organisms, which could help doctors see where to cut during brain surgery.
Article Synopsis
- Tumor cells adapt their metabolism to support uncontrolled growth by requiring sufficient levels of NAD and NADPH.
- *NAD is a key cofactor for important enzymes like PARPs and sirtuins, while NADPH helps regulate cellular redox status.
- *The review discusses strategies for targeting the enzymes that sustain the NAD/NADPH pool in colorectal cancer and how these enzymes interact with NADP(H).
Article Synopsis
- ALDH1A3 is an enzyme involved in converting aldehydes to carboxylic acids and is linked to cancer stem cells, which are associated with higher cancer relapse risks and poor outcomes.
- Researchers characterized NR6, a new selective inhibitor of ALDH1A3, showing it effectively targets cancer cells and binds to a unique site in the enzyme.
- NR6 exhibits anti-metastatic properties and reduces cancer stem cell markers, suggesting it could be a valuable candidate for further research in treating glioblastoma and colorectal cancers.
Article Synopsis
- * Treatments that inhibit these enzymes could be an effective approach to cancer therapy.
- * A new series of compounds called imidazo[1,2-]pyridines were developed as inhibitors targeting the ALDH1A family, with one compound showing promising efficacy as a new competitive inhibitor for the ALDH1A3 isoform.
Article Synopsis
- Dehydrogenases are enzymes that are crucial for various biological processes, including pathogen survival and cancer development.
- This review focuses on NAD-dependent dehydrogenases related to human diseases and highlights recent drug development efforts aimed at inhibiting these enzymes.
- Additionally, the text discusses the molecular mechanisms of inhibition and presents important structures of molecules designed to target these enzymes in the context of cancer and infectious diseases.
Article Synopsis
- * Aldehyde dehydrogenase 1A3 is overexpressed in these resistant cells and targeting this enzyme could potentially improve treatment outcomes for GBM.
- * A new class of imidazo[1,2-]pyridine derivatives has been identified as effective inhibitors of aldehyde dehydrogenase 1A3, showing significant efficacy against GBM stem-like cells and representing a promising strategy for combating this deadly cancer.
The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima.
Acta Crystallogr F Struct Biol Commun
November 2019
Domain swapping is a widespread oligomerization process that is observed in a large variety of protein families. In the large superfamily of substrate-binding proteins, non-monomeric members have rarely been reported. The arginine-binding protein from Thermotoga maritima (TmArgBP), a protein endowed with a number of unusual properties, presents a domain-swapped structure in its dimeric native state in which the two polypeptide chains mutually exchange their C-terminal helices.
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