Impact of Insulin Delivery Method on Hypoglycemia Incidence in Pediatric Type 1 Diabetes Mellitus Patients.

Introduction: Insulin therapy of pediatric patients with type 1 diabetes mellitus (T1DM) is highly demanding due to their dynamic growth, development and different daily life activities.

Goal: To determine the optimal insulin delivery method for the prevention of hypoglycemia recorded by continuous monitoring of glucose in patients with insulin pump and PEN.

Material And Methods: The study included patients up to 18 years of age with diagnosed T1DM and treated with insulin pump and by insulin therapy with PEN at the Pediatric Clinic of the Clinical Center in Sarajevo.

Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children.

Introduction: Epilepsy is one of the most common neurological diseases in childhood and adolescence. Carbamazepine (CBZ) and valproate (VPA) have been widely used as the first generation of antiepileptic drugs (AED).

Aim: The aim of the study has been to evaluate and compare the effect of CBZ and VPA monotherapy on aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) serum levels in children.

Productive Cough in Children and Adolescents - View from Primary Health Care System.

Cough is one of the most common symptoms that doctor faces in working with pediatric population, and according to some characteristics of cough, doctors can often conclude localization, and sometimes even the nature of the disease that causes it. Cough is not only the physiological defense reaction, but a symptom of a disease. According to duration it can be acute, chronic and recidivist, recurrent and persistent, strong or discreet, caused by changes in body position and changes in outside temperature.

Hypothyroidism in Pediatric Population - Bosnian and Herzegovinian Situation.

Introduction: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages.

Goal: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality.

Evaluation and Treatment of Anemia in Premature Infants.

Introduction: Anemia in preterm infants is the pathophysiological process with greater and more rapid decline in hemoglobin compared to the physiological anemia in infants. There is a need for transfusions and administration of human recombinant erythropoietin.

Aim: To determine the frequency of anemia in premature infants at the Pediatric Clinic, University Clinical Center Sarajevo, as well as parameter values in the blood count of premature infants and to explore a relationship between blood transfusions with the advent of intraventricular hemorrhage (determine treatment outcome in preterm infants).

Video-assisted thoracoscopic lobectomy for congenital cystic adenomatoid malformations.

Aim The aim was to show rare cases of congenital cystic adenomatoid malformation (CCAM) and the manner of its surgical treatment with video-assisted thoracoscopic surgery (VATS). Methods Two male and one female child, 7, 4 and 3 years of age were treated for symptoms of cough and high temperature in district hospitals. In all three children laboratory blood tests and chest radiography were done.

Socio-demographic Characteristics of Patients with Diagnosis of Leukemia in Bosnia and Herzegovina During Six-year Period.

Introduction: Malignancies in children are second most frequent cause of death after accidents in pediatric age, while leukemias represents 30% of all malignancies of children age.

Aim: To present the social and demographic characteristics of patients with a diagnosis of leukemia in Bosnia and Herzegovina during six years period.

Patients And Methods: The study included 97 patients (from birth to 18 years old) with diagnosis of acute leukemia.

[Etiology of lymphadenopathy in childhood].

Background: To establish etiology and level of prevalence of lymphadenopathy in children.

Methods: One hundred and fifteen children aged 0-15 years with diagnosed lymphadenopathy at the Pediatric Clinic in Sarajevo during 2008 were included in the study. It analyzed age, sex, etiology and distribution and prevalence of lymphadenopathy.

Metabolic control of TYPE 1 Diabetes in children treated with insulin pump therapy.

In this paper we present study of metabolic control in children suffering from TYPE 1 Diabetes Mellitus (T1DM) who use insulin pump (IP) therapy, and who were treated at Paediatric Clinic in Sarajevo. In retrospective study we followed all T1DM patients with IP therapy introduced in the period from 1st March 2005 to 1st September 2008. We analyzed their age and sex structure, therapy before IP use, and the metabolic control of T1DM represented with glycosylated haemoglobin (HbA1c) value just before and 6 months after IP therapy introducing.

[Autoimmune hemolytic anemia refractory to corticosteroids and high dosage immunoglobulin therapy].

We report about very rare case of autoimune hemolytic anemia (AIHA) with "warm" antibodies in eight months old boy. Diagnosis was set up according blood picture results, distinct anaemia in blood picture, positive Coombs test (IgG) for "warm" antibodies. Therapy with high doses of corticosteroids, with immunoglobulins, with two exchange transfusions and with frequent transfusions of deplasmatic erythrocytes (DPE) was without good result.

The results of Hodgkin lymphoma treatment in children in the period 1997-2006.

In this paper we present the study of chemotherapy and radiotherapy treatment success in children suffering from Hodgkin's disease (HD) that were treated at Hematology-oncology Department of Pediatric Clinic in Sarajevo. In retrospective study we followed all patients with HD aged 0-15 who were diagnosed with and treated for HD at Pediatric Clinic in Sarajevo over the last 10 years (1st of January 1997 - 31st of December 2006). Until 2000 we used combination of chemotherapy and radiotherapy according to UKCCSG HD 9201 treatment protocol, and after the year 2000 protocol UKCCSG HD 2000 (ChlVPP / ABVD) was applied.

[Clinical features of sideropenic anemias in infants and small children].

Unlabelled: The aim of the paper is to present the main clinical features of iron-deficiency anemia (IDA) in infants and in small children. IDA is the most frequent anemia in childhood word-wide. In retrospective study we explore go anemic children with Hb < 110 g/l and 30 children with Hb > 110 g/l, aged 6-24 months.

[Clinical and hematologic features of pediatric leukemias].

Aim Of Investigation: to present main clinical and hematologic features of pediatric leukemias treated at Hematooncologic department of Pediatric Clinic in Sarajevo during last 7 years.

Patients And Methods: In retrospective study we followed up children with leukemia aged 0-15 who were treated during period of 01.01.

[Staphylococcus pneumonia--complications].

The paper presents the case of a 4-year-old child who was admitted with the diagnosis Dg: Pleuropneumonia lat. sin, while in the further course as a suspicion due to progressive flow as staphylococcus pneumonia. The illness is complex in terms of treatment.

[Acute lymphoblastic leukaemia as a secondary malignoma after treatment of acute myeloic leukaemia (AML/M4)].

We report about very rare case of ten years old boy with diagnose of acute myeloic leukaemia which was diagnosed in his age of five (March of 2000) at Pediatric Clinic in Sarajevo. In the first phase of the complete remission autologic bone marrow transplantation was done in Italy (Ancona). Just 7 months after transplantation boy had relaps of illness in the form of acute lymphoblastic leukaemia (ALL/L2).

Heart murmur and anaemia in the pediatric population.

Innocent heart murmurs are hearth murmurs that occur in patients with a normal heart structure. They do not represent a disease of the heart and vascular system, and should not be treated as such. Iron-deficiency anaemia often causes, along with other symptoms, systolic heart murmurs and tachycardia.

[The results of treatment children's Hodgkin lymphoma at pediatric clinic in Sarajevo].

Unlabelled: The aim of this study is to estimate the eficacy of citostatic and radiotherapy in treatment of Hodgkin disease (HD) on Hematology-oncology Department of Pediatric Clinic in Sarajevo (Bosnia and Herzegovina).

Patients And Methods: In retrospective study we followed all patients with HD in the period of 7 years (01.01 1997-31.

[Congenital hypoplastic anemia (Diamond-Blackfan anemia)].

We report two cases of very rare congenital hypoplastic anemia (Diamond-Blackfan anemia) in children. Both patients were boys admitted to our Clinic as severe anemia of unknown etiology, and had been previously treated in their Cantonal hospitals. Diagnose of congenital hypoplastic anemia was set up according: anamnesis, clinical picture with dominant features of anemia, cytomorphologic finding of peripheral blood picture, according blood marrow aspirate finding and according erithropoetin level level in blood.

[Morbus Albers Schonberg osteopetrosis].

The patient presented has bone disease, so called "mramor disease". The disease is characterized by insuffiticnty of ostcoclasts which results n persisting of primary spongiosis without normal eroding and bone rebuilding. The discase is diagnosed by X rays where the bone density is increased.

[Effects of iron therapy on motor and mental development of infants and small children suffering from iron deficiency anaemia].

Unlabelled: The aim of this paper is to establish the effect of iron therapy on mental and motor development in children suffering from iron deficiency anaemia by Bayley Scales of Infant Development (BSID).

Patients And Methods: In prospective study were enroled 90 anemic children with Hb < 110 g/l and 30 healthy children with Hb > 110 g/l, all of them 6-24 months of age.

Results: Indexes of mental development (MDI) before and 3 months after iron therapy for group of patients with severe and mild form of anemia (Hb < 95) did not show statisticaly significant difference (p > 0.

[Modern approach to diagnosis and therapy in childhood leukemias].

Leukemias are the most common malignancies in children. More than 80% leukemias in childhood are acute (non mature) lymphoblastic leukemias (ALL), and the rest are acute myeloid leukemias (AML). Chronic leukemias are very rare, and they are almost always chronic myclogeneous leukemia (CML).

[Infection as a complication of treatment of acute leukemia in children].

Aim: Preventing and successful treatment of infections which are complications during treatment of acute leucosis in children. We analyzed a group of children who were treated at our Clinic in the last five-years period

Patients And Methods: In retrospective study we analyzed children who were treated at our Clinic during last five years. We analysed 56 children, and in 42 of them whole treatment was performed at our Clinic.

[Diagnostic value and cytomorphologic findings in bone marrow punctures in children with severe deficiency anemia].

Aims: To determine the diagnostic and prognostic value the bone marrow aspiration in children with severe deficiency anaemia.

Patients And Methods: In this retrospective study we analysed 75 children 0-4 years of age who were diagnosed and treated from severe anaemia (Hb < 8g/dl) at Haematologic outpatient and hospital department of Pediatric Clinic in Sarajevo in period of 01.01.