Lime and orange essential oils and d-limonene as a potential COVID-19 inhibitor: Computational, , and cytotoxicity analysis.

The COVID-19 pandemic has substantially impacted the world health systems, causing public health concerns, and the search for new compounds with antiviral activity is of extreme interest. Natural molecules with bioactive potential are a trend, with essential oils (Eos) being the focus of recent studies. Thus, this study evaluates the d-limonene inhibitory activities in the viral genome of SARS-CoV-2 and analyzes the cytotoxic potential and safety profile of d-limonene and lime and orange EOs with a high content of d-limonene.

Assessment of potential in vitro toxicity of L. and DC. leaves water extracts.

Medicinal plants have been employed as an alternative method to treat diabetes. One is , a plant from the Amazon region (Northern Brazil), which is morphologically similar to , a plant easily found in Southern Brazil. Thus, this study aimed to assess the potential toxicity of and 's leaves water extracts.

Anti-inflammatory activity of root extract: phytochemical characterization and pharmacologic potential of this under-investigated species.

(Pohl) D. Don roots have been widely used in folk medicine for treating inflammatory conditions. However, few studies have elucidated compounds that justify their traditional use.

Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity.

Background: Irinotecan (IRI) is a widely used chemotherapeutic drug, mostly used for first-line treatment of colorectal and pancreatic cancer. IRI doses are usually established based on patient's body surface area, an approach associated with large inter-individual variability in drug exposure and high incidence of severe toxicity. Toxic and therapeutic effects of IRI are also due to its active metabolite SN-38, reported to be up to 100 times more cytotoxic than IRI.

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis.

Acne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics.

Pesticide exposure and health conditions among orange growers in Southern Brazil.

This study aimed to evaluate the exposure to pesticides through the biomarkers analysis, as well as life habits and use of Personal Protective Equipment (PPE) in a group of farmers who grow citrus in the Vale do Caí region, in Rio Grande do Sul, southern Brazil. The study population consisted of 73 volunteer farmers, 45 males and 28 females, aged between 13 and 69 years old. The control group consisted of 30 individuals who were not exposed to pesticides.

Pharmacogenetic and Pharmacokinetic Dose Individualization of the Taxane Chemotherapeutic Drugs Paclitaxel and Docetaxel.

Background: The taxane drugs paclitaxel and docetaxel, widely used on cancer chemotherapy, are currently dosed mainly based on body-surface area. This approach is associated with wide interindividual variability in drug exposure, leading to suboptimal dosing for many patients.

Methods: The available evidence supporting dose individualization strategies for paclitaxel and docetaxel were reviewed, focusing mainly on the application of therapeutic drug monitoring by a priori pharmacogenetic data or a posteriori drug measurements in biological fluids.

Beyond organoleptic characteristics: the pharmacological potential of flavonoids and their role in leukocyte migration and in L-selectin and β2-integrin expression during inflammation.

Flavonoids are compounds responsible for several organoleptic characteristics of plant-derived foods. They are also bioactive compounds with antiinflammatory role. Different mechanisms for this activity have been reported, but their effects on cell migration are not fully understood.

Evaluation of the pharmacological activity of the Alternanthera brasiliana aqueous extract.

Context: Alternanthera brasiliana (L.) Kuntze (Amarantaceae) is widely used in Brazilian traditional medicine as an analgesic, anti-inflammatory and antibacterial.

Objective: To investigate the potential anti-inflammatory, analgesic, anxiolytic, and locomotor effect of the infusions in preclinical models.

Pharmacological evaluation of Copaifera multijuga oil in rats.

Context: Copaiba oil is an oleoresin made up of resin acids and volatile compounds, and it is obtained by tapping the trunks of trees that are members of the Copaifera L. (Leguminoseae) genus and are found in tropical parts of Latin America.

Objective: This study analyzed the chemical composition of Copaifera multijuga Hayne oil and conducted preclinical trials to investigate anti-inflammatory effects and any action it may have on the central nervous system (CNS) of rats.

Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils.

Flavonoids are polyphenols that are ubiquitous in plants and frequently consumed in the diet. They are suggested to have many beneficial actions on human health, including anti-inflammatory activity. Their properties have been studied in a number of cell types, but little is known about their effects on neutrophil biology.

Oxidative stress and DNA damage in older adults that do exercises regularly.

Objectives: Free radicals may damage lipids, proteins and DNA, which may lead to critical diseases in the aging. This work evaluated levels of malondialdehyde (MDA), glutathione peroxidase (GPx) and DNA damage by comet assay (SCGE) in older adults that do exercises regularly.

Design And Methods: 110 females, aged 66.