Addressing health disparities in Hispanic breast cancer: accurate and inexpensive sequencing of BRCA1 and BRCA2.

Background: Germline mutations in the BRCA1 and BRCA2 genes account for 20-25 % of inherited breast cancers and about 10 % of all breast cancer cases. Detection of BRCA mutation carriers can lead to therapeutic interventions such as mastectomy, oophorectomy, hormonal prevention therapy, improved screening, and targeted therapies such as PARP-inhibition. We estimate that African Americans and Hispanics are 4-5 times less likely to receive BRCA screening, despite having similar mutation frequencies as non-Jewish Caucasians, who have higher breast cancer mortality.

Tactile cues for orienting pilots during hover over moving targets.

Introduction: Providing information via the tactile sensory system allows the pilot to increase awareness without further taxing the visual and auditory perceptual systems. In this study, tactile cues were presented to pilots for target orientation during a simulated helicopter extraction over a moving target. The efficacy of the cues provided by the tactile system was assessed under various conditions (rested vs.