Characterization of and Plasmids of a ST11 Outbreak Clone.

The most common resistance mechanism to carbapenems is the production of carbapenemases. In 2021, the Pan American Health Organization warned of the emergence and increase in new carbapenemase combinations in in Latin America. In this study, we characterized four isolates harboring and from an outbreak during the COVID-19 pandemic in a Brazilian hospital.

Building an antimicrobial stewardship program: A narrative of six years under the Donabedian perspective.

Antimicrobial resistance (AMR) is increasing and represents one of the world's major challenges. AMR increase morbimortality, length of hospital stay and costs. Antimicrobial Stewardship Programs (ASP) are one of the key strategies to promote the rational use of antimicrobials since AMR is mostly driven by antimicrobial consumption.

Polymyxin Resistance Among XDR ST1 Carbapenem-Resistant Clone Expanding in a Teaching Hospital.

is an opportunistic pathogen primarily associated with multidrug-resistant nosocomial infections, for which polymyxins are the last-resort antibiotics. This study investigated carbapenem-resistant strains exhibiting an extensively drug-resistant (XDR) phenotype, including four isolates considered locally pan drug-resistant (PDR), isolated from inpatients during an outbreak at a teaching hospital in Brazil. ApaI DNA macrorestriction followed by PFGE clustered the strains in three pulsotypes, named A to C, among carbapenem-resistant strains.

Endotoxins in surgical instruments of hip arthroplasty.

Objective: To investigate endotoxins in sterilized surgical instruments used in hip arthroplasties.

Method: A descriptive exploratory study conducted in a public teaching hospital. Six types of surgical instruments were selected, namely: acetabulum rasp, femoral rasp, femoral head remover, chisel box, flexible bone reamer and femoral head test.