Publications by authors named "Edna L Tamez-Gomez"
Background And Aims: Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- and middle-income countries are lower due to deficiencies in multilevel factors, including access to timely diagnosis, risk-stratified therapy, and comprehensive supportive care. This retrospective study aimed to analyze outcomes for pediatric ALL at 16 centers in Mexico.
Methods: Patients <18 years of age with newly diagnosed B- and T-cell ALL treated between January 2011 and December 2019 were included.
Article Synopsis
- Acute lymphoblastic leukemia (ALL) is linked to both genetic and environmental factors, with single nucleotide polymorphisms (SNPs) in specific genes potentially increasing risk in pediatric populations in Mexico.
- A multicenter study was conducted comparing children diagnosed with ALL to healthy controls, examining the impact of SNPs rs2910164, rs12803915, rs11614913, and rs3746444 through DNA analysis.
- The results indicated a significant association of the rs3746444 SNP with a higher risk of developing ALL, particularly in males, highlighting the need for further research on the genetic mechanisms behind ALL.
Article Synopsis
- Recent studies have highlighted the significance of long non-coding RNAs (lncRNAs) in the development of leukemia, suggesting their potential use as biomarkers for diagnosis and prognosis in childhood acute lymphoblastic leukemia (ALL).
- A microarray analysis focused on children with B-lineage ALL found that high expression of lncRNAs LINC00152 and LINC01013 was linked to increased risks of early relapse and mortality, with specific hazard ratios calculated for different expression levels.
- The findings suggest that LINC00152 might play a regulatory role in certain biological processes related to cell adhesion and could serve as a promising biomarker for predicting relapse in children suffering from B-ALL.
Introduction: Development of inhibitors is the most serious complication in patients with haemophilia (PWH). The prevalence of inhibitors in patients with severe haemophilia A (HA) is approximately 25%-30%. Inhibitor prevalence differs among populations.
View Article and Find Full Text PDFUmbilical cord blood transplantation using nonmyeloablative conditioning is currently considered by many as a valid potential alternative for any patient who requires an unrelated donor allograft and who is without a suitably matched and readily available volunteer. Dimethyl sulfoxide (DMSO) has been used for years as a cryoprotectant agent; it acts by penetrating the cell and binding water molecules and it has been described as harmless for the individual who receives it in limited amounts. In this paper, we describe 3 cases of DMSO-induced toxicities and briefly review the most common adverse reactions of the DMSO when used as a cryopreservation agent for the long-term storage of cord blood cells.
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