Publications by authors named "Edmundo Damiani Bertoli"
Cardiovascular benefits of statin plus ezetimibe combination therapy versus statin monotherapy in acute coronary syndrome: a meta-analysis of randomized controlled trials.
Coron Artery Dis
January 2025
Background: The efficacy of adding ezetimibe to statin therapy for event reduction in patients with acute coronary syndromes (ACS) remains a topic of ongoing debate.
Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ezetimibe plus statin versus statin monotherapy in patients with ACS. We searched PubMed, Embase, and Cochrane for eligible trials.
Article Synopsis
- Small anterior communicating artery (ACoA) aneurysms are challenging for neurosurgeons due to their risky location and the potential for severe complications if they rupture; both surgical clipping and endovascular treatments are common approaches.
- A meta-analysis was conducted across thirteen studies involving 637 patients to compare the efficacy and outcomes of surgical clipping versus endovascular treatment techniques, primarily focusing on coiling.
- Results demonstrated similar overall outcomes for both methods, but surgical clipping had a significantly lower retreatment rate (0% vs. 18% for endovascular), while endovascular treatment had slightly higher mortality and complication rates, emphasizing the importance of factors such as surgeon expertise and patient characteristics in treatment decisions.
Cardiovascular Benefits of GLP-1 Receptor Agonists in Patients Living with Obesity or Overweight: A Meta-analysis of Randomized Controlled Trials.
Am J Cardiovasc Drugs
July 2024
Article Synopsis
- GLP-1 receptor agonists (GLP-1 RAs) have been shown to effectively aid in weight loss, but their impact on cardiovascular health for people with obesity or overweight is uncertain.* -
- A systematic review and meta-analysis of 13 randomized controlled trials involving over 30,000 patients found that GLP-1 RAs significantly lowered both systolic and diastolic blood pressure and reduced the incidence of myocardial infarction compared to a placebo.* -
- However, there were no significant effects noted on other cardiovascular issues like unstable angina, stroke, atrial fibrillation, or deep vein thrombosis in the same patient population.*
Introduction: Stent-assisted coil embolization (SACE) for cerebral aneurysms requires dual antiplatelet therapy (DAPT), commonly clopidogrel plus aspirin is preferable to ticagrelor or prasugrel plus aspirin. However, there are few studies assessing the safety of the association of ticagrelor or prasugrel plus aspirin.
Objectives: Compare the safety of newer P2Y12 inhibitors with clopidogrel in patients that underwent a SACE for cerebral aneurysms.
Safety and efficacy of sotagliflozin in patients with type II diabetes mellitus and chronic kidney disease: a meta-analysis of randomized controlled trials.
J Nephrol
May 2024
Article Synopsis
- Sotagliflozin, a medication for type 2 diabetes, was evaluated for its effects on patients with type 2 diabetes and chronic kidney disease through a systematic analysis of clinical trials.
- The study showed that Sotagliflozin significantly reduced HbA1c levels and body weight compared to a placebo, with over 11,000 patients followed for about 16 months.
- However, it also raised concerns, as patients experienced more side effects like reduced kidney function, genital infections, diarrhea, and volume depletion, indicating a need for careful consideration before use.