appear resistant to trans-synaptic tau propagation.

Alzheimer's disease is the most common cause of dementia in the elderly, prompting extensive efforts to pinpoint novel therapeutic targets for effective intervention. Among the hallmark features of Alzheimer's disease is the development of neurofibrillary tangles comprised of hyperphosphorylated tau protein, whose progressive spread throughout the brain is associated with neuronal death. Trans-synaptic propagation of tau has been observed in mouse models, and indirect evidence for tau spread via synapses has been observed in human Alzheimer's disease.

Reeling from news that reelin defends the brain against Alzheimer's.

In a recent study, Lopera and colleagues investigate a person with extreme resilience to autosomal-dominant familial Alzheimer's disease, which they attribute to a rare variant in the RELN gene encoding reelin..

improves cognitive and motor function of a rat model of acute radiation syndrome in the elevated plus maze.

We reported recently that the elevated plus maze is a good tool for evaluating cognitive and motor functional changes in gamma-irradiated rats as a model for new drug evaluation and monitoring. The capacity of to mitigate radiation-induced brain injury is currently unknown. We therefore assessed the effects of the neuroprotective medicinal plant , on the cognitive and motor changes in this murine model of acute radiation syndrome.