Publications by authors named "Edivaldo Dos Santos Rodrigues"
Article Synopsis
- SARS-CoV-2 is recognized as one of the most significant pandemics in recent history, prompting a search for effective non-biological antiviral treatments.
- Researchers are focusing on repurposing existing drugs and have identified key host factors, such as the molecular chaperone GRP78, that facilitate the virus's entry into cells.
- TL1228, a small molecule found through in silico screening, inhibits the interaction between SARS-CoV-2 and GRP78, significantly reducing viral activity and influencing immune response and inflammation markers in lab studies.
Solidagenone from Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway.
Ivanilson Pimenta Santos Laís Peres Silva Dahara Keyse Carvalho Silva Bruna Padilha Zurita Claro Dos Reis Temistocles Barroso de Oliveira Edivaldo Dos Santos Rodrigues
Pharmaceuticals (Basel)
February 2024
Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it necessary to search for new anti-inflammatory drugs. Here, we investigated the anti-inflammatory activity of solidagenone.
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