Antibacterial Sesquiterpene Lactones from Kaunia lasiophthalma.

Phytochemical study of the species Kaunia lasiophthalma enabled the isolation of three undescribed and three known guaianolide-type sesquiterpene lactones, and one new benzofuran. The bioguided fractionation methodology was successful in detecting antimicrobial metabolites against Staphylococcus aureus strains and permitted the description of undescribed guaianolide-type sesquiterpene lactones with substitution patterns matching all those described in the Oxylobinae subtribe.

Selective extraction of antimicrobial agents from by supercritical fluid carbon dioxide: phytochemical profile.

The goals of this study were to determine the phytochemical profile of and to evaluate the ability of supercritical fluids (ScFCO) to selectively extract the metabolites responsible for the bioactivity. This species has simple aromatic compounds and lignan monomers, as well as glycerides containing epoxidized saturated fatty acids. Regarding the extraction by ScFCO, the extracts showed a higher antimicrobial activity against human pathogenic strains, with respect to the ethanolic extracts obtained from plant residues after extraction by ScFCO.