Publications by authors named "Edith D Beishuizen"
[Urinary tract infection caused by Candida while using an SGLT-2 inhibitor].
Ned Tijdschr Geneeskd
August 2023
Background: Sodium glucose transporter 2 (SGLT-2) inhibitors are a relatively new group of antidiabetic drugs. The renal glucose reabsorption is blocked resulting in higher glucose levels in the urine (glucosuria). Recently studies are being conducted into the medications nephrological and cardiovascular potential.
View Article and Find Full Text PDFArticle Synopsis
- The SCORE2 cardiovascular disease (CVD) risk models, designed for widespread use in Europe, were evaluated in a diverse Dutch population concerning ethnicity and socioeconomic status, which are not explicitly included as risk factors.
- A large cohort of 155,000 individuals aged 40-70 was studied from 2007 to 2020, revealing significant discrepancies between predicted and observed CVD events, particularly among lower socioeconomic and ethnic subgroups.
- The findings indicated that while the SCORE2 models had moderate performance overall, they significantly underpredicted CVD risk outcomes, especially in specific subgroups like Surinamese individuals, suggesting the need for adjustments in these models for better accuracy.
Background: Socioeconomic status and ethnicity are not incorporated as predictors in country-level cardiovascular risk charts on mainland Europe. The aim of this study was to quantify the sex-specific cardiovascular death rates stratified by ethnicity and socioeconomic factors in an urban population in a universal healthcare system.
Methods: Age-standardized death rates (ASDR) were estimated in a dynamic population, aged 45-75 in the city of The Hague, the Netherlands, over the period 2007-2018, using data of Statistics Netherlands.
We present the case of a 58-year-old woman with multiple brain infarcts and livedo racemosa, a distinctive branched and irregular skin discoloration, on the trunk and limbs. Skin biopsy showed intimal proliferation with occlusion of a subcutaneous arteriole. We diagnosed Sneddon's syndrome, a rare neurocutaneous disorder likely caused by a noninflammatoryvasculopathy.
View Article and Find Full Text PDFBackground: The burden of cardiovascular disease in diabetes mellitus type 2 (DM2) patients is variable. We hypothesize that metabolic syndrome (MS) and low-grade systemic inflammation modify the extent of atherosclerosis in DM2.
Methods: Vascular phenotype was determined using the following endothelium-related, hemostatic, and sonographic endpoints in 62 DM2 patients with mild dyslipidemia: sVCAM, sE-selectin, von Willebrand factor (VWF), fibrinogen, s-thrombomodulin (sTM), tPA, PAI-1, flow-mediated dilation (FMD), and intima media thickness (IMT).
Objective: Coronary artery disease is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the prevalence of silent myocardial ischemia (SMI) and the effect of statin therapy on SMI in type 2 diabetic patients without manifest cardiovascular disease.
Research Design And Methods: A randomized, placebo-controlled, double-blind trial was performed in 250 patients with type 2 diabetes without manifest cardiovascular disease.
Objective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes and is preceded by endothelial dysfunction. Flow-mediated dilation (FMD) is a noninvasive technique for measuring endothelial dysfunction. We aimed to determine the effect of long-term statin therapy versus placebo on FMD in patients with type 2 diabetes without manifest CVD.
View Article and Find Full Text PDFMorbidity and mortality in patients with type 2 diabetes mellitus is largely dominated by the occurrence of cardiovascular disease (CVD). Treatment of known risk factors of CVD has proven to be beneficial in terms of reduction in risk of major CVD events in the general population. Recent trials have provided information on the treatment of hyperglycaemia, hypertension, dyslipidaemia and platelet aggregation in the patient with type 2 diabetes.
View Article and Find Full Text PDFObjective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the effect of statin therapy versus placebo on the progression of carotid intima-media thickness (IMT) in type 2 diabetic patients without manifest CVD.
Research Design And Methods: A randomized, placebo-controlled, double-blind clinical trial was performed in 250 patients with type 2 diabetes.