Batch and Continuous Flow Total Synthesis of Cannabidiol.

Herein, we present a comprehensive total synthesis of cannabidiol integrating both batch and continuous flow conditions. Our approach is planned to streamline the synthesis of olivetolic acid derivatives and utilize an enantiomerically pure monoterpene moiety obtained from naturally occurring (R)-(+)-limonene by photocatalysis. Key reactions, including the synthesis of olivetolic ester and a Friedel-Crafts alkylation, are successfully adapted to continuous flow, resulting in improved yields and selectivities.

Stability of di-butyl-dichalcogenide-capped gold nanoparticles: experimental data and theoretical insights.

Metals capped with organochalcogenides have attracted considerable interest due to their practical applications, which include catalysis, sensing, and biosensing, due to their optical, magnetic, electrochemical, adhesive, lubrication, and antibacterial properties. There are numerous reports of metals capped with organothiol molecules; however, there are few studies on metals capped with organoselenium or organotellurium. Thus, there is a gap to be filled regarding the properties of organochalcogenide systems which can be improved by replacing sulfur with selenium or tellurium.

Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae.

Background: Resistance to fluconazole, a commonly used azole antifungal, is a challenge for the treatment of fungal infections. Resistance can be mediated by overexpression of ABC transporters, which promote drug efflux that requires ATP hydrolysis. The Pdr5p ABC transporter of Saccharomyces cerevisiae is a well-known model used to study this mechanism of antifungal resistance.

A one-pot glycerol-based additive-blended ethyl biodiesel production: a green process.

N-methyl-2-pyrrolidonium methyl sulfonate, a Brønsted acid ionic liquid, promoted the transesterification of soybean oil with ethanol giving a high quality fatty acid ethyl ester. At the end of the reaction, after distillation of excess of ethanol, spontaneous phase separation took place. While the clear upper phase corresponded to the ethyl ester, the lower phase was composed of a mixture of glycerol byproduct and the catalyst.

2-Cyclo-hexyl-4-methyl-tetra-hydro-pyran-4-ol.

In the title compound, C(12)H(22)O(2), the 4-methyl-tetra-hydro-pyran-4-ol ring adopts a conformation close to that of a chair and with the two O atoms syn; the cyclo-hexyl group occupies an equatorial position and adopts a chair conformation. In the crystal packing, supra-molecular chains along the b axis are sustained by O-H⋯O hydrogen bonds. These are connected into undulating layers in the ab plane by C-H⋯O inter-actions.