Publications by authors named "Edina Gabriella Szekely"
Article Synopsis
- Intravenous administration of rt-PA for acute ischemic stroke (AIS) has limited success and can cause intracerebral hemorrhage (ICH) in about 6-8% of patients.
- This study focused on measuring levels of α2-plasmin inhibitor (α2-PI) during thrombolysis in 421 AIS patients to see if these levels could predict therapy outcomes.
- Results showed that higher α2-PI levels on admission correlated with better long-term outcomes, indicating that α2-PI may be a useful biomarker for predicting recovery in stroke patients.
The ever-increasing research efforts to develop new antithrombotic therapies have led to the reassessment of the role of alpha-2-plasmin inhibitor (α-PI) in pathological conditions. In particular, experimental stroke studies have suggested correlation between increased free α2-PI level and mortality. However there are only a small number of well-characterized and specific assays available for the measurements of free α-PI.
View Article and Find Full Text PDFIn this observational study we investigated whether levels of factor XIII (FXIII) and its major polymorphisms affect the outcome of thrombolysis by recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke (AIS) patients. Study cohort included 132 consecutive AIS patients undergoing i.v.
View Article and Find Full Text PDFIntroduction: Plasma factor VIII (FVIII) and von Willebrand factor (VWF) levels have been associated with the rate and severity of arterial thrombus formation and have been linked to outcomes following thrombolytic therapy in acute myocardial infarction patients. Here, we aimed to investigate FVIII and VWF levels during the course of thrombolysis in acute ischemic stroke (AIS) patients and to find out whether they predict long-term outcomes.
Materials And Methods: Study population included 131 consecutive AIS patients (median age: 69 years, 60.