Polymorphisms associated with oral clefts as potential susceptibility markers for oral and breast cancer.

Objective: To evaluate the association of single nucleotide polymorphisms (SNPs) in genes/loci consistently altered in nonsyndromic oral clefts in patients with oral and breast cancer in a Brazilian population.

Design: This case-control study evaluated the association of SNPs in IRF6 (rs642961), WNT3A (rs708111), GSK3β (rs9879992), 8q24 (rs987525) and WNT11 (rs1533767), representing regions consistently identified as of susceptibility for oral clefts, with oral cancer (oral squamous cell carcinoma) and breast cancer. Logistic regression analyses were used for confounding adjustments, and p values ≤0.

Intraoral stents in preventing adverse radiotherapeutic effects in lip cancer patients.

Aim: To fabricate and evaluate the efficacy of individualized intraoral stents to minimize the potential side effects of radiation on oral tissues in patients with early stages of lip cancer.

Background: Lower lip cancer is a common tumor found almost exclusively in middle-aged and elderly males. Surgery is the most common treatment of choice, although for less extensive lesions, exclusive radiotherapy may be preferred.

Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population.

Background: Epidemiological studies have indicated a higher incidence of breast and gastric cancer in patients with nonsyndromic cleft lip with or without cleft palate (NSCL ± P) and their relatives, which can be based on similar genetic triggers segregated within family with NSCL ± P.

Methods: This multicenter study evaluated the association of 9 single nucleotide polymorphisms (SNP) in AXIN2 and CDH1, representing genes consistently altered in breast and gastric tumors, with NSCL ± P in 223 trios (father, mother and patient with NSCL ± P) by transmission disequilibrium test (TDT).

Results: Our results showed that the minor A allele of rs7210356 (p = 0.

Oral Candida species in head and neck cancer patients treated by radiotherapy.

Objective: This paper aimed to identify and quantify Candida on head and neck irradiated patients with two comparative elderly populations.

Materials And Methods: Saliva was sampled from 29 head and neck irradiated patients (group 1) 34 non-institutionalized elderly patients (group 2) and 29 institutionalized elders (group 3) and matched by age. For quantification, the obtained saliva was sewed on CHROMagar Candida(®), which was used also for presumptive identification of Candida, API 20C AUX(®), microculture and RAPD (OPE-18) were used for the final identification.