Publications by authors named "Edilson Torres-Gonzales"
Article Synopsis
- Alcohol use disorders significantly increase the risk of developing acute respiratory distress syndrome, but the mechanisms behind this are not well understood due to limitations in animal models for studying alcohol consumption.
- A new study used a model that simulates chronic alcohol consumption combined with binge drinking to explore its effects on lung injury and inflammation.
- Results showed that this alcohol exposure led to neutrophil accumulation and airway hyper-responsiveness in the lungs, indicating that even mild alcohol consumption can initiate inflammatory responses in lung tissue.
Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice.
Am J Respir Cell Mol Biol
September 2017
Chronic alcohol exposure is a clinically important risk factor for the development of acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). However, the mechanisms by which alcohol sensitizes the lung to development of this disease are poorly understood. We determined the role of the antifibrinolytic protein plasminogen activator inhibitor-1 (PAI-1) in alcohol enhancement of experimental endotoxin-induced ALI.
View Article and Find Full Text PDFBackground: Long-term success in lung transplantation is limited by obliterative bronchiolitis (OB). Presently, complete understanding of the mechanisms of OB has been elusive. Bone marrow-derived mesenchymal stem cells (MSC) have been shown to modulate repair of the injured lung in multiple disease models.
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