Publications by authors named "Edikarlos M Brasil"
Herein, we report the preparation of 1,2,4-thiadiazinane 1,1-dioxides from reaction of β-aminoethane sulfonamides with dichloromethane, dibromomethane and formaldehyde as methylene donors. The β-aminoethane sulfonamides were obtained through sequential Michael addition of amines to α,β-unsaturated ethenesulfonyl fluorides followed by further DBU mediated sulfur(vi) fluoride exchange (SuFEx) reaction with amines at the S-F bond.
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- Inhibition of mushroom tyrosinase was effectively achieved using synthetic dihydropyrano[3,2-b]chromenediones, particularly DHPC04, which showed strong activity comparable to the standard inhibitor kojic acid.
- Kinetic studies indicated that these compounds act as competitive inhibitors at the L-DOPA binding site of the enzyme.
- Molecular modeling further revealed key insights into how these compounds interact with the copper active site of tyrosinase.