Publications by authors named "Edgar R Pastene-Navarrete"
Article Synopsis
- Type 2 diabetes and obesity are global issues, and dietary polyphenols like anthocyanins from berries can help alleviate symptoms of these diseases.
- Research focused on two specific anthocyanins (DG and DS) to see if they could counteract the negative metabolic effects of the antipsychotic medication olanzapine, which can lead to metabolic syndrome.
- Results indicated that while DG and DS effectively reduced fat accumulation in liver cells, they did not restore normal insulin signaling in muscle cells affected by olanzapine.
Introduction: Plants from Amaryllidaceae family are of interest since they produce a particular type of alkaloid useful for the treatment of neurodegenerative diseases of the central nervous system, such as Galanthamine. Given the low content of these secondary metabolites in the plant, it is necessary to study mechanisms to increase the productivity of them.
Objective: To obtain fast qualitative and quantitative analysis of the alkaloids and extend the understanding of biosynthesis and metabolism in these kinds of plants.
Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture.
Food Chem Toxicol
October 2019
In this study we evaluate the chemical composition and neuroprotective effects of alkaloid fractions of the Amaryllidaceae species Rhodophiala pratensis, Rhodolirium speciosum, Phycella australis and Phaedranassa lehmannii. Gas chromatography-mass spectrometry (GC/MS) enable the identification of 41 known alkaloids. Rhodolirium speciosum and Rhodophiala pratensis were the most active extracts against acetylcholinesterase (AChE), with IC values of 35.
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