Publications by authors named "Edgar P Anaya"
Article Synopsis
- - Acute lower respiratory tract infection (ALRI) is a leading cause of child mortality globally, particularly affecting children in Papua New Guinea (PNG) due to Streptococcus pneumoniae.
- - Researchers conducted whole-exome sequencing on children in PNG and found a specific genetic variant (a single-nucleotide variant in the COQ6 gene) that is linked to higher morbidity from ALRI, with evidence from both human and mouse studies supporting its role.
- - The COQ6 variant plays a significant role in the biosynthesis of ubiquinone and impacts how the immune system responds to infections, highlighting a new genetic risk factor for pneumonia in PNG and the enzyme's involvement in inflammatory responses.
Macrophage adhesion and stretching have been shown to induce interleukin (IL)-1β production, but the mechanism of this mechanotransduction remains unclear. Here we specify the molecular link between mechanical tension on tissue-resident macrophages and activation of the NLRP3 inflammasome, which governs IL-1β production. NLRP3 activation enhances antimicrobial defense, but excessive NLRP3 activity causes inflammatory tissue damage in conditions such as pulmonary fibrosis and acute respiratory distress syndrome.
View Article and Find Full Text PDFAsplenia imparts susceptibility to life-threatening sepsis with encapsulated bacteria, such as the pneumococcus. However, the cellular components within the splenic environment that guard against pneumococcal bacteremia have not been defined. The actin-bundling protein L-plastin (LPL) is essential for the generation of marginal zone B cells and for anti-pneumococcal host defense, as revealed by a mouse model of genetic LPL deficiency.
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